PDF(Pubmed)
Abstract：
In recent years, the arrival of the immunotherapy industry has introduced the possibility of providing transformative, durable, and potentially curative outcomes for various forms of malignancies. However, further research has shown that there are a number of issues that significantly reduce the effectiveness of immunotherapy, especially in solid tumors. First of all, these problems are related to the protective mechanisms of the tumor and its microenvironment. Currently, major efforts are focused on overcoming protective mechanisms by using different adoptive cell therapy variants and modifications of genetically engineered constructs. In addition, a complex workforce is required to develop and implement these treatments. To overcome these significant challenges, innovative strategies and approaches are necessary to engineer more powerful variations of immunotherapy with improved antitumor activity and decreased toxicity. In this review, we discuss recent innovations in immunotherapy aimed at improving clinical efficacy in solid tumors, as well as strategies to overcome the limitations of various immunotherapies.
摘要：
近年来,免疫疗法行业的到来带来了提供变革的可能性，耐用,以及各种恶性肿瘤的潜在治愈结果。然而,进一步的研究表明，有许多问题显着降低了免疫疗法的有效性，尤其是实体瘤。首先,这些问题与肿瘤及其微环境的保护机制有关。目前,主要努力集中在通过使用不同的过继细胞疗法变体和基因工程构建体的修饰来克服保护机制。此外,需要复杂的劳动力来开发和实施这些治疗方法。为了克服这些重大挑战，创新的策略和方法是必要的工程更强大的免疫疗法的变化,提高抗肿瘤活性和降低毒性.在这次审查中,我们讨论了最近的免疫疗法创新，旨在提高实体瘤的临床疗效，以及克服各种免疫疗法局限性的策略。
