PDF(Pubmed)
Abstract：
The incidences of anogenital HPV-related cancers in women are on the rise; this is especially true for anal cancer. Medical societies are now beginning to recommend anal cancer screening in certain high-risk populations, including high-risk women with a history of genital dysplasia. The aim of this study is to investigate national anogenital HPV cancer trends as well as the role of demographics, deprivation, and ethnicity on anogenital cancer incidence in England, in an attempt to better understand this cohort of women which is increasingly affected by anogenital HPV-related disease. Demographic data from the Clinical Outcomes and Services Dataset (COSD) were extracted for all patients diagnosed with anal, cervical, vulval and vaginal cancer in England between 2014 and 2020. Outcomes included age, ethnicity, deprivation status and staging. An age over 55 years, non-white ethnicity and high deprivation are significant risk factors for late cancer staging, as per logistic regression. In 2019, the incidences of anal and vulval cancer in white women aged 55-74 years surpassed that of cervical cancer. More needs to be done to educate women on HPV-related disease and their lifetime risk of these conditions.
摘要：
女性肛门生殖器HPV相关癌症的发病率正在上升;对于肛门癌尤其如此。医学界现在开始建议在某些高危人群中进行肛门癌筛查，包括有生殖器发育不良病史的高危女性。这项研究的目的是调查全国肛门生殖器HPV癌症趋势以及人口统计学的作用，剥夺,和种族对英格兰肛门生殖器癌发病率的影响，试图更好地了解这一越来越多地受到肛门生殖器HPV相关疾病影响的女性队列。从临床结果和服务数据集（COSD）中提取所有诊断为肛门，子宫颈,2014年至2020年英国的外阴和阴道癌。结果包括年龄，种族,剥夺状态和分期。年龄超过55岁，非白人种族和高度剥夺是晚期癌症分期的重要危险因素，根据逻辑回归。2019年，55-74岁白人女性的肛门癌和外阴癌发病率超过了宫颈癌。需要做更多的工作来教育女性HPV相关疾病及其终生风险。
