PDF(Pubmed)
Abstract：
Esophageal carcinoma is the sixth-leading cause of cancer death worldwide. A precursor to esophageal adenocarcinoma (EAC) is Barrett\'s Esophagus (BE). Early-stage diagnosis and treatment of esophageal neoplasia (Barrett\'s with high-grade dysplasia/intramucosal cancer) increase the five-year survival rate from 10% to 98%. BE is a global challenge; however, current endoscopes for early BE detection are costly and require extensive infrastructure for patient examination and sedation. We describe the design and evaluation of the first prototype of ScanCap, a high-resolution optical endoscopy system with a reusable, low-cost tethered capsule, designed to provide high-definition, blue-green illumination imaging for the early detection of BE in unsedated patients. The tethered capsule (12.8 mm diameter, 35.5 mm length) contains a color camera and rotating mirror and is designed to be swallowed; images are collected as the capsule is retracted manually via the tether. The tether provides electrical power and illumination at wavelengths of 415 nm and 565 nm and transmits data from the camera to a tablet. The ScanCap prototype capsule was used to image the oral mucosa in normal volunteers and ex vivo esophageal resections; images were compared to those obtained using an Olympus CV-180 endoscope. Images of superficial capillaries in intact oral mucosa were clearly visible in ScanCap images. Diagnostically relevant features of BE, including irregular Z-lines, distorted mucosa, and dilated vasculature, were clearly visible in ScanCap images of ex vivo esophageal specimens.
摘要：
食管癌是全球癌症死亡的第六大原因。食管腺癌（EAC）的前兆是Barrett食管（BE）。早期诊断和治疗食管肿瘤（Barrett伴高度异型增生/粘膜内癌）可将5年生存率从10％提高到98％。是一个全球性的挑战；然而，目前用于早期BE检测的内窥镜成本很高，需要大量的基础设施来进行患者检查和镇静。我们描述了ScanCap的第一个原型的设计和评估，一个高分辨率的光学内窥镜系统，低成本系留胶囊，旨在提供高清晰度，蓝绿照明成像用于早期检测未镇静患者的BE。系留胶囊（直径12.8毫米，35.5毫米长）包含彩色相机和旋转镜，并设计为可吞咽；在胶囊通过系绳手动缩回时收集图像。系绳提供415nm和565nm波长的电力和照明,并将数据从相机传输到平板电脑。ScanCap原型胶囊用于对正常志愿者和离体食管切除的口腔粘膜进行成像；将图像与使用OlympusCV-180内窥镜获得的图像进行比较。在ScanCap图像中，完整口腔粘膜中的浅表毛细血管图像清晰可见。BE的诊断相关特征，包括不规则的Z线，粘膜扭曲，和扩张的脉管系统，在离体食管标本的ScanCap图像中清晰可见。
