PDF(Pubmed)
Abstract：
Cardiomyocytes are the largest cell type that make up the heart and confer beating activity to the heart. The proper differentiation of cardiomyocytes relies on the efficient transmission and perception of differentiation cues from several signaling pathways that influence cardiomyocyte-specific gene expression programs. Signaling pathways also mediate intercellular communications to promote proper cardiomyocyte differentiation. We have reviewed the major signaling pathways involved in cardiomyocyte differentiation, including the BMP, Notch, sonic hedgehog, Hippo, and Wnt signaling pathways. Additionally, we highlight the differences between different cardiomyocyte cell lines and the use of these signaling pathways in the differentiation of cardiomyocytes from stem cells. Finally, we conclude by discussing open questions and current gaps in knowledge about the in vitro differentiation of cardiomyocytes and propose new avenues of research to fill those gaps.
摘要：
心肌细胞是构成心脏并赋予心脏跳动活动的最大细胞类型。心肌细胞的适当分化依赖于来自影响心肌细胞特异性基因表达程序的几个信号通路的分化线索的有效传递和感知。信号通路还介导细胞间通讯以促进适当的心肌细胞分化。我们综述了参与心肌细胞分化的主要信号通路,包括BMP,缺口,索尼克刺猬,河马,和Wnt信号通路。此外,我们强调了不同心肌细胞系之间的差异，以及这些信号通路在心肌细胞从干细胞分化中的应用。最后,最后，我们讨论了关于心肌细胞体外分化的悬而未决的问题和目前的知识空白，并提出了新的研究途径来填补这些空白。
