PDF(Pubmed)
Abstract：
It is generally accepted that atherosclerosis is a chronic inflammatory disease. The link between atherosclerosis and other inflammatory diseases such as psoriasis, type 2 diabetes mellitus (T2DM), and rheumatoid arthritis (RA) via metabolic, inflammatory, and immunoregulatory pathways is well established. The aim of our review was to summarize the associations between selected microRNAs (miRs) and long non-coding RNAs (lncRNAs) and atherosclerosis, psoriasis, T2DM, and RA. We reviewed the role of miR-146a, miR-210, miR-143, miR-223, miR-126, miR-21, miR-155, miR-145, miR-200, miR-133, miR-135, miR-221, miR-424, let-7, lncRNA-H19, lncRNA-MEG3, lncRNA-UCA1, and lncRNA-XIST in atherosclerosis and psoriasis, T2DM, and RA. Extracellular vesicles (EVs) are a method of intracellular signal transduction. Their function depends on surface expression, cargo, and the cell from which they originate. The majority of the studies that investigated lncRNAs and some miRs had relatively small sample sizes, which limits the generalizability of their findings and indicates the need for more research. Based on the studies reviewed, miR-146a, miR-155, miR-145, miR-200, miR-133, and lncRNA-H19 are the most promising potential biomarkers and, possibly, therapeutic targets for atherosclerosis as well as T2DM, RA, and psoriasis.
摘要：
一般认为动脉粥样硬化是一种慢性炎性疾病。动脉粥样硬化和其他炎症性疾病如牛皮癣之间的联系，2型糖尿病（T2DM），和类风湿性关节炎（RA）通过代谢，炎症，和免疫调节途径已经建立。我们综述的目的是总结选定的microRNAs（miRs）和长链非编码RNAs（lncRNAs）与动脉粥样硬化之间的关联。牛皮癣,T2DM,RA。我们回顾了miR-146a的作用，miR-210，miR-143，miR-223，miR-126，miR-21，miR-155，miR-145，miR-200，miR-133，miR-135，miR-221，miR-424，let-7，lncRNA-H19，lncRNA-MEG3，lncRNA-UCA1和lncRNA-XIST在动脉粥样硬化和银屑病中的作用，T2DM,RA。细胞外囊泡(EV)是细胞内信号转导的方法。它们的功能取决于表面表达，cargo,以及它们起源的细胞。大多数研究lncRNAs和一些miRs的研究样本相对较小，这限制了他们的研究结果的普遍性，并表明需要更多的研究。根据审查的研究，miR-146a,miR-155，miR-145，miR-200，miR-133和lncRNA-H19是最有前途的潜在生物标志物，可能,动脉粥样硬化和T2DM的治疗靶点，RA,牛皮癣。
