PDF(Pubmed)
Abstract：
Background: Severe coagulation abnormalities are common in patients with COVID-19 infection. We aimed to investigate the relationship between pro-inflammatory cytokines and coagulation parameters concerning socio-demographic, clinical, and laboratory characteristics. Methods: Our study included patients hospitalized during the second wave of COVID-19 in the Republic of Serbia. We collected socio-demographic, clinical, and blood-sample data for all patients. Cytokine levels were measured using flow cytometry. Results: We analyzed data from 113 COVID-19 patients with an average age of 58.15 years, of whom 79 (69.9%) were male. Longer duration of COVID-19 symptoms before hospitalization (B = 69.672; p = 0.002) and use of meropenem (B = 1237.220; p = 0.014) were predictive of higher D-dimer values. Among cytokines, higher IL-5 values significantly predicted higher INR values (B = 0.152; p = 0.040) and longer prothrombin times (B = 0.412; p = 0.043), and higher IL-6 (B = 0.137; p = 0.003) predicted longer prothrombin times. Lower IL-17F concentrations at admission (B = 0.024; p = 0.050) were predictive of higher INR values, and lower IFN-γ values (B = -0.306; p = 0.017) were predictive of higher aPTT values. Conclusions: Our findings indicate a significant correlation between pro-inflammatory cytokines and coagulation-related parameters. Factors such as the patient\'s level of education, gender, oxygen-therapy use, symptom duration before hospitalization, meropenem use, and serum concentrations of IL-5, IL-6, IL-17F, and IFN-γ were associated with worse coagulation-related parameters.
摘要：
背景：严重的凝血异常在COVID-19感染患者中很常见。我们的目的是调查促炎细胞因子和凝血参数之间的关系，涉及社会人口统计学，临床,和实验室的特点。方法：我们的研究包括塞尔维亚共和国第二波COVID-19住院的患者。我们收集了社会人口统计，临床,和所有患者的血液样本数据。使用流式细胞术测量细胞因子水平。结果：我们分析了113例平均年龄为58.15岁的COVID-19患者的数据，其中79人（69.9％）为男性。住院前COVID-19症状持续时间较长（B=69.672；p=0.002）和使用美罗培南（B=1237.220；p=0.014）是D-二聚体值较高的预测因素。在细胞因子中，更高的IL-5值显着预测更高的INR值（B=0.152;p=0.040）和更长的凝血酶原时间（B=0.412;p=0.043），和较高的IL-6(B=0.137;p=0.003)预测较长的凝血酶原时间。入院时较低的IL-17F浓度（B=0.024;p=0.050）预示着较高的INR值，和较低的IFN-γ值（B=-0.306;p=0.017）预示着较高的aPTT值。结论：我们的发现表明促炎细胞因子与凝血相关参数之间存在显着相关性。患者的教育水平等因素,性别,使用氧疗，住院前的症状持续时间，美罗培南使用，和血清IL-5，IL-6，IL-17F的浓度，和IFN-γ与较差的凝血相关参数相关。
