PDF(Pubmed)
Abstract：
Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFAs), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are recommended as beneficial dietary supplements for enhancing cognitive function. Although fish oil (FO) is renowned for its abundant n-3 PUFA content, combining FO with other natural products is considered as a viable option to support the sustainable development of FO products. This review aims to provide comprehensive insights into the advanced effects of combining FO or its components of DHA and EPA with natural products on protecting cognitive function. In two double-blind random control trials, no advanced effects were observed for adding curcumin to FO on cerebral function protection. However, 16 week\'s treatment of FO combined with vitamin E did not yield any advanced effects in cognitive factor scores. Several preclinical studies have demonstrated that combinations of FO with natural products can exhibit advanced effects in addressing pathological components in cognitive impairment, including neuroinflammation, oxidative stress, and neuronal survival. In conclusion, evidence from clinical trials for beneficial use of FO and natural ingredients combination is lacking. Greater cohesion is needed between preclinical and clinical data to substantiate the efficacy of FO and natural product combinations in preventing or slowing the progression of cognitive decline.
摘要：
长链多不饱和ω-3脂肪酸（n-3PUFA），特别是二十二碳六烯酸（DHA）和二十碳五烯酸（EPA），建议作为有益的膳食补充剂，以增强认知功能。尽管鱼油（FO）以其丰富的n-3PUFA含量而闻名，将FO与其他天然产品相结合被认为是支持FO产品可持续发展的可行选择。这篇综述旨在提供全面的见解，以了解将FO或其DHA和EPA成分与天然产物结合在保护认知功能上的高级作用。在两个双盲随机对照试验中,在FO中添加姜黄素对脑功能的保护作用没有进展。然而,16周的FO联合维生素E治疗在认知因子评分方面没有产生任何进展效应。一些临床前研究表明，FO与天然产物的组合可以在解决认知障碍的病理成分方面表现出先进的效果。包括神经炎症,氧化应激，和神经元存活。总之,缺乏临床试验中有关FO和天然成分组合的有益使用的证据。临床前和临床数据之间需要更大的凝聚力，以证实FO和天然产品组合在预防或减缓认知衰退进展方面的功效。
