PDF(Pubmed)
Abstract：
Amid the deepening imbalance in the supply and demand of allogeneic organs, xenotransplantation can be a practical alternative because it makes an unlimited supply of organs possible. However, to perform xenotransplantation on patients, the source animals to be used must be free from infectious agents. This requires the breeding of animals using assisted reproductive techniques, such as somatic cell nuclear transfer, embryo transfer, and cesarean section, without colostrum derived in designated pathogen-free (DPF) facilities. Most infectious agents can be removed from animals produced via these methods, but several viruses known to pass through the placenta are not easy to remove, even with these methods. Therefore, in this narrative review, we examine the characteristics of several viruses that are important to consider in xenotransplantation due to their ability to cross the placenta, and investigate how these viruses can be detected. This review is intended to help maintain DPF facilities by preventing animals infected with the virus from entering DPF facilities and to help select pigs suitable for xenotransplantation.
摘要：
在同种异体器官供需失衡加剧的情况下，异种移植可能是一种实用的替代方法，因为它使器官的无限供应成为可能。然而,对病人进行异种移植，要使用的源动物必须没有传染性病原体。这就需要使用辅助生殖技术来饲养动物,例如体细胞核移植，胚胎移植,和剖腹产,没有来自指定的无病原体（DPF）设施的初乳。大多数感染因子可以从通过这些方法产生的动物中去除，但是几种已知通过胎盘的病毒不容易清除，即使是这些方法。因此,在这篇叙述性评论中，我们研究了几种病毒的特征，这些病毒在异种移植中很重要，因为它们具有穿越胎盘的能力，并研究如何检测这些病毒。这篇综述旨在通过防止感染该病毒的动物进入DPF设施来帮助维护DPF设施，并帮助选择适合异种移植的猪。
