PDF(Pubmed)
Abstract：
Diabetic retinopathy (DR) is one of the most severe complications of diabetes mellitus and potentially leads to significant visual impairment and blindness. The complex mechanisms involved in the pathological changes in DR make it challenging to achieve satisfactory outcomes with existing treatments. Diets conducive to glycemic control have been shown to improve outcomes in diabetic patients, thus positioning dietary interventions as promising avenues for DR treatment. Investigations have demonstrated that natural products (NPs) may effectively manage DR. Many types of natural compounds, including saponins, phenols, terpenoids, flavonoids, saccharides, alkaloids, and vitamins, have been shown to exert anti-inflammatory, antioxidant, anti-neovascular, and antiapoptotic effects in vivo and in vitro. Nevertheless, the clinical application of NPs still faces challenges, such as suboptimal specificity, poor bioavailability, and a risk of toxicity. Prospective clinical studies are imperative to validate the therapeutic potential of NPs in delaying or preventing DR.
摘要：
糖尿病视网膜病变（DR）是糖尿病最严重的并发症之一，可能导致严重的视力障碍和失明。DR病理变化中涉及的复杂机制使现有治疗方法取得令人满意的结果具有挑战性。有助于血糖控制的饮食已被证明可以改善糖尿病患者的预后。因此将饮食干预定位为DR治疗的有希望的途径.研究表明，天然产物（NPs）可以有效地管理DR。许多类型的天然化合物，包括皂苷,酚类物质,萜类化合物,黄酮类化合物，糖类，生物碱，和维生素,已经被证明具有抗炎作用，抗氧化剂，抗新生血管，体内和体外抗凋亡作用。然而，NPs的临床应用仍然面临挑战，例如次优特异性，生物利用度差,和毒性的风险。前瞻性临床研究对于验证NPs在延迟或预防DR方面的治疗潜力至关重要。
