PDF(Pubmed)
Abstract：
The endothelial barrier plays a critical role in immune defense against bacterial infection. Efficient interactions between neutrophils and endothelial cells facilitate the activation of both cell types. However, neutrophil activation can have dual effects, promoting bacterial clearance on one hand while triggering inflammation on the other. In this review, we provide a detailed overview of the cellular defense progression when neutrophils encounter bacteria, focusing specifically on neutrophil-endothelial interactions and endothelial activation or dysfunction. By elucidating the underlying mechanisms of inflammatory pathways, potential therapeutic targets for inflammation caused by endothelial dysfunction may be identified. Overall, our comprehensive understanding of neutrophil-endothelial interactions in modulating innate immunity provides deeper insights into therapeutic strategies for infectious diseases and further promotes the development of antibacterial and anti-inflammatory drugs.
摘要：
内皮屏障在抵抗细菌感染的免疫防御中起关键作用。嗜中性粒细胞和内皮细胞之间的有效相互作用促进两种细胞类型的激活。然而,嗜中性粒细胞活化有双重作用,一方面促进细菌清除，另一方面引发炎症。在这次审查中,当嗜中性粒细胞遇到细菌时，我们提供了细胞防御进展的详细概述，特别关注中性粒细胞-内皮相互作用和内皮激活或功能障碍。通过阐明炎症途径的潜在机制，可以确定由内皮功能障碍引起的炎症的潜在治疗靶点.总的来说,我们对中性粒细胞-内皮相互作用在调节先天免疫中的全面了解,为感染性疾病的治疗策略提供了更深入的见解,并进一步促进了抗菌和抗炎药的开发.
