PDF(Pubmed)
Abstract：
Ewingella americana is a Gram-negative rod that belongs to the order Enterobacterales and the family Yersiniaceae and was first identified in 1983 from 10 clinical strains in the United States of America. The present study aimed to identify all the published cases of E. americana in the literature, describe the epidemiological, clinical, and microbiological characteristics, and provide data regarding its antimicrobial resistance, treatment, and outcomes. A narrative review was performed based on a PubMed and Scopus databases search. In total, 16 studies provided data on 19 patients with infections by E. americana. The median age of the patients was 55 years, and 47.4% were male. The most common infections were those of the bloodstream, the respiratory tract, and the peritoneal cavity. Antimicrobial resistance to cephalosporins, aminoglycosides, and the combination of trimethoprim with sulfamethoxazole was minimal, and these were the most commonly used antimicrobials for treating these infections. No included study provided information on the genetic or molecular mechanism of this pathogen\'s antimicrobial resistance. The overall mortality was minimal, with only one patient with bacteremia succumbing to the infection. Further studies are needed to better understand this microorganism, its pathogenic potential in humans, and the genetic and molecular mechanisms underlying its antimicrobial resistance, for which very little evidence exists to date.
摘要：
美洲Ewingella是一种革兰氏阴性杆菌属，属于肠杆菌和耶尔森氏菌科，于1983年在美国的10种临床菌株中首次发现。本研究旨在确定文献中所有已发表的美洲大肠杆菌病例，描述流行病学，临床,和微生物学特征，并提供有关其抗菌素耐药性的数据，治疗,和结果。基于PubMed和Scopus数据库搜索进行了叙述性审查。总的来说,16项研究提供了19例感染美洲大肠杆菌患者的数据。患者的中位年龄为55岁，男性占47.4%。最常见的感染是血液感染，呼吸道,还有腹膜腔.对头孢菌素的抗菌素耐药性，氨基糖苷类,甲氧苄啶与磺胺甲恶唑的联合使用很少，这些是治疗这些感染最常用的抗菌药物。没有纳入的研究提供了有关该病原体耐药性的遗传或分子机制的信息。总死亡率很低，只有一名菌血症患者死于感染。需要进一步的研究来更好地了解这种微生物，它在人类中的致病潜力，以及其抗菌素耐药性的遗传和分子机制，迄今为止证据很少。
