PDF(Pubmed)
Abstract：
BACKGROUND: The escalating prevalence of ESBL-producing Enterobacteriaceae in Qatar\'s pediatric population, especially in community-onset febrile urinary tract infections (FUTIs), necessitates a comprehensive investigation into this concerning trend.
RESULTS: Over the course of one year, a total of 459 infants were diagnosed and subsequently treated for UTIs. Cases primarily occurred in infants aged over 60 days, predominantly non-Qatari females born from term pregnancies. Notably, E. coli and K. pneumoniae were the most frequently identified organisms, accounting for 79.7% and 9.8% in the ESBL group and 57.2% and 18.7% in the non-ESBL group, respectively. Interestingly, hydronephrosis emerged as the most prevalent urological anomaly detected in both ESBL (n = 10) and other organism (n = 19) groups.
METHODS: In this retrospective cohort study conducted in Qatar, we meticulously evaluated the prevalence of pediatric FUTIs. Our study focused on febrile infants aged less than 1 year, excluding those with urine samples not obtained through a catheter.
CONCLUSIONS: E. coli and K. pneumoniae prevailed as the predominant causative agents in febrile children in Qatar, with hydronephrosis being identified as the most common urological anomaly. Moreover, our findings suggested that gentamicin served as a viable non-carbapenem option for hospitalized ESBL cases, while oral nitrofurantoin showed considerable promise for uncomplicated ESBL UTIs.
RESULTS: Over the course of one year, a total of 459 infants were diagnosed and subsequently treated for UTIs. Cases primarily occurred in infants aged over 60 days, predominantly non-Qatari females born from term pregnancies. Notably, E. coli and K. pneumoniae were the most frequently identified organisms, accounting for 79.7% and 9.8% in the ESBL group and 57.2% and 18.7% in the non-ESBL group, respectively. Interestingly, hydronephrosis emerged as the most prevalent urological anomaly detected in both ESBL (n = 10) and other organism (n = 19) groups.
METHODS: In this retrospective cohort study conducted in Qatar, we meticulously evaluated the prevalence of pediatric FUTIs. Our study focused on febrile infants aged less than 1 year, excluding those with urine samples not obtained through a catheter.
CONCLUSIONS: E. coli and K. pneumoniae prevailed as the predominant causative agents in febrile children in Qatar, with hydronephrosis being identified as the most common urological anomaly. Moreover, our findings suggested that gentamicin served as a viable non-carbapenem option for hospitalized ESBL cases, while oral nitrofurantoin showed considerable promise for uncomplicated ESBL UTIs.
摘要：
背景：在卡塔尔的儿科人群中，产ESBL肠杆菌科细菌的患病率不断上升，特别是在社区发作的发热性尿路感染（FUTIs）中，有必要对此趋势进行全面调查。
结果：在一年的时间里，共有459名婴儿被诊断并随后接受了UTI治疗.病例主要发生在60天以上的婴儿中，主要是足月妊娠出生的非卡塔尔女性。值得注意的是,大肠杆菌和肺炎克雷伯菌是最常见的生物，ESBL组分别占79.7%和9.8%,非ESBL组分别占57.2%和18.7%,分别。有趣的是,在ESBL（n=10）和其他生物体（n=19）组中，肾积水是最常见的泌尿系统异常。
方法：在卡塔尔进行的这项回顾性队列研究中，我们仔细评估了小儿FUTIs的患病率.我们的研究集中在1岁以下的发热婴儿，不包括那些尿液样本不是通过导管获得的。
结论：E.大肠杆菌和肺炎克雷伯菌是卡塔尔发热儿童的主要病原体，肾积水被认为是最常见的泌尿系统异常。此外，我们的研究结果表明，庆大霉素作为一种可行的非碳青霉烯类药物用于住院ESBL病例，而口服呋喃妥因对不复杂的ESBLUTI显示出相当大的希望。
结果：在一年的时间里，共有459名婴儿被诊断并随后接受了UTI治疗.病例主要发生在60天以上的婴儿中，主要是足月妊娠出生的非卡塔尔女性。值得注意的是,大肠杆菌和肺炎克雷伯菌是最常见的生物，ESBL组分别占79.7%和9.8%,非ESBL组分别占57.2%和18.7%,分别。有趣的是,在ESBL（n=10）和其他生物体（n=19）组中，肾积水是最常见的泌尿系统异常。
方法：在卡塔尔进行的这项回顾性队列研究中，我们仔细评估了小儿FUTIs的患病率.我们的研究集中在1岁以下的发热婴儿，不包括那些尿液样本不是通过导管获得的。
结论：E.大肠杆菌和肺炎克雷伯菌是卡塔尔发热儿童的主要病原体，肾积水被认为是最常见的泌尿系统异常。此外，我们的研究结果表明，庆大霉素作为一种可行的非碳青霉烯类药物用于住院ESBL病例，而口服呋喃妥因对不复杂的ESBLUTI显示出相当大的希望。
