PDF(Pubmed)
Abstract：
Interactions between drugs are a common problem in Intensive Care Unit patients, as they mainly have a critical condition that often demands the administration of multiple drugs simultaneously. Antibiotics are among the most frequently used medications, as infectious diseases are often observed in ICU patients. In this review, the most important antibiotic-drug interactions, based on the pharmacokinetic and pharmacodynamic mechanisms, were gathered together and described. In particular, some of the most important interactions with main groups of antibacterial drugs were observed in patients simultaneously prescribed oral anticoagulants, NSAIDs, loop diuretics, and valproic acid. As a result, the activity of drugs can be increased or decreased, as dosage modification might be necessary. It should be noted that these crucial interactions can help predict and avoid negative consequences, leading to better patient recovery. Moreover, since there are other factors, such as fluid therapy or albumins, which may also modify the effectiveness of antibacterial therapy, it is important for anaesthesiologists to be aware of them.
摘要：
药物之间的相互作用是重症监护病房患者的常见问题，因为他们主要有一个关键的条件，往往需要同时服用多种药物。抗生素是最常用的药物之一，因为在ICU患者中经常观察到感染性疾病。在这次审查中,最重要的抗生素-药物相互作用，基于药代动力学和药效学机制，他们聚集在一起描述。特别是,在同时服用口服抗凝剂的患者中观察到一些与主要抗菌药物的最重要的相互作用，NSAIDs,loop利尿剂，和丙戊酸。因此,药物的活性可以增加或减少，因为剂量修改可能是必要的。应该指出的是，这些关键的相互作用可以帮助预测和避免负面后果，导致更好的患者康复。此外，因为还有其他因素，如液体疗法或白蛋白，这也可能改变抗菌治疗的有效性，麻醉师意识到它们是很重要的。
