PDF(Pubmed)
Abstract：
Bacteria are a major cause of superficial eye infections, especially in children. The present study aimed to (i) determine the antimicrobial susceptibility patterns of ocular bacterial pathogens recovered in 20 laboratories during the period 2020-2021 and (ii) compare these results to those from three studies of the same design conducted in 2004, 2009, and 2015 in Germany. Cut-off values defined by EUCAST were used as breakpoints. A total of 1366 bacterial isolates were collected. The most frequent ocular specimens were conjunctival smears (54.3%). Susceptibility rates of Staphylococcus aureus (n = 594), Haemophilus influenzae (n = 178), and Streptococcus pneumoniae (n = 149) to chloramphenicol, gentamicin, kanamycin, neomycin, levofloxacin, ofloxacin, and oxytetracycline were >90% each. Overall, only minor changes in resistance levels were observed in the period since 2004. Therefore, all tested antimicrobials can still be recommended for local therapy of ocular surface infections.
摘要：
细菌是眼睛浅表感染的主要原因,尤其是儿童。本研究旨在（i）确定2020-2021年期间在20个实验室中回收的眼部细菌病原体的抗菌敏感性模式，以及（ii）将这些结果与2004年，2009年和2015年在德国进行的相同设计的三项研究进行比较。由EUCAST定义的截止值用作断点。总共收集了1366个细菌分离物。最常见的眼部标本是结膜涂片（54.3％）。金黄色葡萄球菌的敏感率（n=594），流感嗜血杆菌（n=178），和肺炎链球菌（n=149）氯霉素，庆大霉素,卡那霉素,新霉素,左氧氟沙星,氧氟沙星,和土霉素各>90%。总的来说,自2004年以来，仅观察到阻力水平的微小变化。因此,所有测试的抗菌药物仍可推荐用于眼表感染的局部治疗。
