PDF(Pubmed)
Abstract：
Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor expressed in many tissues, including skin, where it is essential for maintaining skin barrier permeability, regulating cell proliferation/differentiation, and modulating antioxidant and inflammatory responses upon ligand binding. Therefore, PPARγ activation has important implications for skin homeostasis. Over the past 20 years, with increasing interest in the role of PPARs in skin physiopathology, considerable effort has been devoted to the development of PPARγ ligands as a therapeutic option for skin inflammatory disorders. In addition, PPARγ also regulates sebocyte differentiation and lipid production, making it a potential target for inflammatory sebaceous disorders such as acne. A large number of studies suggest that PPARγ also acts as a skin tumor suppressor in both melanoma and non-melanoma skin cancers, but its role in tumorigenesis remains controversial. In this review, we have summarized the current state of research into the role of PPARγ in skin health and disease and how this may provide a starting point for the development of more potent and selective PPARγ ligands with a low toxicity profile, thereby reducing unwanted side effects.
摘要：
过氧化物酶体增殖物激活受体γ(PPARγ)是在许多组织中表达的转录因子。包括皮肤,对于保持皮肤屏障的通透性至关重要，调节细胞增殖/分化，并在配体结合时调节抗氧化剂和炎症反应。因此,PPARγ激活对皮肤稳态具有重要意义。在过去的20年里,随着人们对PPARs在皮肤病理生理学中的作用越来越感兴趣，在开发PPARγ配体作为皮肤炎症性疾病的治疗选择方面,人们付出了相当大的努力.此外,PPARγ还调节皮脂腺细胞分化和脂质产生，使其成为炎性皮脂腺疾病如痤疮的潜在目标。大量研究表明，PPARγ在黑色素瘤和非黑色素瘤皮肤癌中也作为皮肤肿瘤抑制因子，但其在肿瘤发生中的作用仍存在争议。在这次审查中,我们总结了PPARγ在皮肤健康和疾病中的作用的研究现状，以及这如何为开发具有低毒性的更有效和选择性的PPARγ配体提供起点。从而减少不必要的副作用。
