PDF(Pubmed)
Abstract：
Macrophages, as important immune cells of the organism, are involved in maintaining intrahepatic microenvironmental homeostasis and can undergo rapid phenotypic changes in the injured or recovering liver. In recent years, the crucial role of macrophage-programmed cell death in the development and regression of liver diseases has become a research hotspot. Moreover, macrophage-targeted therapeutic strategies are emerging in both preclinical and clinical studies. Given the macrophages\' vital role in complex organismal environments, there is tremendous academic interest in developing novel therapeutic strategies that target these cells. This review provides an overview of the characteristics and interactions between macrophage polarization, programmed cell death, related biomarkers, and macrophage-targeted therapies. It aims to deepen the understanding of macrophage immunomodulation and molecular mechanisms and to provide a basis for the treatment of macrophage-associated liver diseases.
摘要：
巨噬细胞,作为生物体的重要免疫细胞，参与维持肝内微环境稳态，并且可以在受损或恢复的肝脏中经历快速的表型变化。近年来,巨噬细胞程序性细胞死亡在肝脏疾病发展和消退中的关键作用已成为研究热点。此外，巨噬细胞靶向治疗策略在临床前和临床研究中都出现。鉴于巨噬细胞在复杂的生物环境中的重要作用，有巨大的学术兴趣在开发新的治疗策略，以这些细胞为目标。这篇综述概述了巨噬细胞极化的特征和相互作用，程序性细胞死亡，相关生物标志物，和巨噬细胞靶向治疗。旨在加深对巨噬细胞免疫调节及分子机制的认识,为巨噬细胞相关性肝病的治疗提供依据。
