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Abstract：
Cholelithiasis is a common biliary tract disease. However, the exact mechanism underlying gallstone formation remains unclear. Mucin plays a vital role in the nuclear formation and growth of cholesterol and pigment stones. Excessive mucin secretion can result in cholestasis and decreased gallbladder activity, further facilitating stone formation and growth. Moreover, gallstones may result in inflammation and the secretion of inflammatory factors, which can further increase mucin expression and secretion to promote the growth of gallstones. This review systematically summarises and analyses the role of mucins in gallstone occurrence and development and its related mechanisms to explore new ideas for interventions in stone formation or recurrence.
摘要：
胆石症是一种常见的胆道疾病。然而,胆结石形成的确切机制尚不清楚.粘蛋白在胆固醇和色素结石的核形成和生长中起着至关重要的作用。粘蛋白分泌过多可导致胆汁淤积和胆囊活动减少，进一步促进结石的形成和生长。此外，胆结石可能导致炎症和炎症因子的分泌，可以进一步增加粘蛋白的表达和分泌，促进胆结石的生长。本文系统地总结和分析了粘蛋白在胆结石发生发展中的作用及其相关机制，为结石形成或复发的干预探索新思路。
