Abstract：
OBJECTIVE: To analyze the clinical features and laboratory indicators in patients with solid malignant tumor-associated venous thromboembolism (Ta-VTE), and to study the risk factors for Ta-VTE.
METHODS: The hospitalized patients with VTE in Guizhou Provincial People\'s Hospital from January to December 2020 were enrolled, and they were divided into Ta-VTE group and pure VTE group based on the presence or absence of solid malignant tumor. The differences in clinical data and laboratory indicators between the two groups were analyzed, and the indicators with significant differences were included in logistic regression model to analyze the risk factors of Ta-VTE.
RESULTS: A total of 288 patients with VTE were included in this study, including 64 cases in Ta-VTE group and 224 cases in pure VTE group, respectively. There were significant differences in the following indexes between the two groups, including the hospitalization time (14.20±15.29 d vs 10.05±6.90 d, t=3.112, P =0.002), pain (35.94% vs 65.18%, χ2=17.554, P =0.000), recent surgery (75.00% vs 37.50%, χ2=28.196, P =0.000), D-dimer [2.8 (0.92, 7.55) μg/ml vs 5.69 (2.25, 13.91) μg/ml, Z=-2.710, P =0.007], PLR[198.59 (139.54, 312.16) vs 149.76 (114.08, 233.66), Z=-2.924, P =0.003] and TBIL[10.90 (7.63, 15.68) μmol/L vs 12.90 (9.33, 18.28) μmol/L, Z=-2.066, P =0.039]. There was no significant difference in the other indicators (P >0.05). The result of multivariate logistic regression analysis showed that elevated PLR (OR =1.003, 95%CI : 1.000-1.006, P =0.027), recent surgery (OR =4.312, 95%CI : 2.093-8.885, P =0.000) and prolonged hospitalization (OR =1.037, 95%CI : 1.002-1.074, P =0.038）were independent risk factors for Ta-VTE. However, pain (OR =0.274, 95%CI : 0.133-0.564, P =0.000) was a protective factor.
CONCLUSIONS: Elevated PLR level, recent surgery and prolonged hospital stay are independent risk factors for Ta-VTE patients, and rational use of these indicators is helpful for the clinical diagnosis and treatment of Ta-VTE patients.
UNASSIGNED: 实体恶性肿瘤相关性静脉血栓患者的临床特征及实验室指标分析.
UNASSIGNED: 分析实体恶性肿瘤相关静脉血栓栓塞症（Ta-VTE）患者的临床特征和实验室指标，研究其危险因素。.
UNASSIGNED: 收集2020年1月至12月在本院住院的静脉血栓患者，根据是否患有实体恶性肿瘤，分为Ta-VET组和单纯VTE组，分析两组患者间的临床资料和实验室指标的差异，将有显著差异的指标纳入logistic回归，分析Ta-VTE的危险因素。.
UNASSIGNED: 本研究共纳入288例静脉血栓患者，其中Ta-VTE组64例，单纯VTE组224例。两组患者间住院时长（14.20±15.29 d vs 10.05±6.90 d, t =3.112, P =0.002）、疼痛患者比例（35.94% vs 65.18%, χ 2=17.554, P =0.000）、近期手术史患者比例（75.00% vs 37.50%，χ 2=28.196, P =0.000）、D-D[2.8（0.92，7.55） μg/ml vs 5.69（2.25，13.91） μg/ml, Z=-2.710, P =0.007]、PLR[198.59（139.54，312.16） vs 149.76（114.08，233.66）, Z=-2.924, P =0.003]、TBIL[10.90（7.63，15.68） μmol/L vs 12.90（9.33，18.28） μmol/L, Z=-2.066, P =0.039]具有显著统计学差异，其余各指标均无明显差异（P >0.05）。多因素logistic回归分析结果显示，PLR水平升高（OR =1.003, 95%CI : 1.000-1.006, P =0.027）、近期手术史（OR =4.312, 95%CI : 2.093-8.885, P =0.000）和住院时间延长（OR =1.037, 95%CI : 1.002-1.074, P =0.038）是恶性实体肿瘤相关静脉血栓栓塞症的独立危险因素；而疼痛（OR =0.274, 95%CI : 0.133-0.564, P = 0.000）是一项保护性因素。.
UNASSIGNED: PLR水平升高、近期手术史和住院时间延长是Ta-VTE患者的独立危险因素，合理利用这些指标有助于Ta-VTE患者的临床诊疗。.
METHODS: The hospitalized patients with VTE in Guizhou Provincial People\'s Hospital from January to December 2020 were enrolled, and they were divided into Ta-VTE group and pure VTE group based on the presence or absence of solid malignant tumor. The differences in clinical data and laboratory indicators between the two groups were analyzed, and the indicators with significant differences were included in logistic regression model to analyze the risk factors of Ta-VTE.
RESULTS: A total of 288 patients with VTE were included in this study, including 64 cases in Ta-VTE group and 224 cases in pure VTE group, respectively. There were significant differences in the following indexes between the two groups, including the hospitalization time (14.20±15.29 d vs 10.05±6.90 d, t=3.112, P =0.002), pain (35.94% vs 65.18%, χ2=17.554, P =0.000), recent surgery (75.00% vs 37.50%, χ2=28.196, P =0.000), D-dimer [2.8 (0.92, 7.55) μg/ml vs 5.69 (2.25, 13.91) μg/ml, Z=-2.710, P =0.007], PLR[198.59 (139.54, 312.16) vs 149.76 (114.08, 233.66), Z=-2.924, P =0.003] and TBIL[10.90 (7.63, 15.68) μmol/L vs 12.90 (9.33, 18.28) μmol/L, Z=-2.066, P =0.039]. There was no significant difference in the other indicators (P >0.05). The result of multivariate logistic regression analysis showed that elevated PLR (OR =1.003, 95%CI : 1.000-1.006, P =0.027), recent surgery (OR =4.312, 95%CI : 2.093-8.885, P =0.000) and prolonged hospitalization (OR =1.037, 95%CI : 1.002-1.074, P =0.038）were independent risk factors for Ta-VTE. However, pain (OR =0.274, 95%CI : 0.133-0.564, P =0.000) was a protective factor.
CONCLUSIONS: Elevated PLR level, recent surgery and prolonged hospital stay are independent risk factors for Ta-VTE patients, and rational use of these indicators is helpful for the clinical diagnosis and treatment of Ta-VTE patients.
UNASSIGNED: 实体恶性肿瘤相关性静脉血栓患者的临床特征及实验室指标分析.
UNASSIGNED: 分析实体恶性肿瘤相关静脉血栓栓塞症（Ta-VTE）患者的临床特征和实验室指标，研究其危险因素。.
UNASSIGNED: 收集2020年1月至12月在本院住院的静脉血栓患者，根据是否患有实体恶性肿瘤，分为Ta-VET组和单纯VTE组，分析两组患者间的临床资料和实验室指标的差异，将有显著差异的指标纳入logistic回归，分析Ta-VTE的危险因素。.
UNASSIGNED: 本研究共纳入288例静脉血栓患者，其中Ta-VTE组64例，单纯VTE组224例。两组患者间住院时长（14.20±15.29 d vs 10.05±6.90 d, t =3.112, P =0.002）、疼痛患者比例（35.94% vs 65.18%, χ 2=17.554, P =0.000）、近期手术史患者比例（75.00% vs 37.50%，χ 2=28.196, P =0.000）、D-D[2.8（0.92，7.55） μg/ml vs 5.69（2.25，13.91） μg/ml, Z=-2.710, P =0.007]、PLR[198.59（139.54，312.16） vs 149.76（114.08，233.66）, Z=-2.924, P =0.003]、TBIL[10.90（7.63，15.68） μmol/L vs 12.90（9.33，18.28） μmol/L, Z=-2.066, P =0.039]具有显著统计学差异，其余各指标均无明显差异（P >0.05）。多因素logistic回归分析结果显示，PLR水平升高（OR =1.003, 95%CI : 1.000-1.006, P =0.027）、近期手术史（OR =4.312, 95%CI : 2.093-8.885, P =0.000）和住院时间延长（OR =1.037, 95%CI : 1.002-1.074, P =0.038）是恶性实体肿瘤相关静脉血栓栓塞症的独立危险因素；而疼痛（OR =0.274, 95%CI : 0.133-0.564, P = 0.000）是一项保护性因素。.
UNASSIGNED: PLR水平升高、近期手术史和住院时间延长是Ta-VTE患者的独立危险因素，合理利用这些指标有助于Ta-VTE患者的临床诊疗。.
摘要：
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