PDF(Pubmed)
Abstract：
BACKGROUND: Endometriosis is a chronic and debilitating disease that can affect the entire reproductive life course of women, with potential adverse effects on pregnancy. The aim of the present study is to investigate the association between hypertensive disorders in pregnancy and endometriosis.
METHODS: Relevant articles were searched from the Cochrane Library, PubMed, Scopus and Web of Science from inception up to December 2023. The full-text observational studies published in English that had a confirmed diagnosis of endometriosis were included. The case group included pregnant women diagnosed with endometriosis at any stage, while the control group consisted of pregnant women who had not been previously diagnosed with endometriosis. Two authors extracted and analyzed the data independently. Disagreements were reconciled by reviewing the full text by a third author. Endnote X9 was used for screening and data extraction. We used fixed and random effects models in Review Manager 5.3 to analyze the pooled data. The quality of the included studies was assessed using the Downs and Black checklist.
RESULTS: Out of the 9863 articles reviewed, 23 were selected for meta-analysis. According to the results of this study, there was an association between endometriosis and gestational hypertension (OR = 1.11, 95% CI: 1.06, 1.16; I2 = 45%, P < 0.00001; N = 8), pre-eclampsia (OR = 1.26, 95% CI: 1.18, 1.36; I2 = 37%, P < 0.00001; N = 12), and hypertensive disorders in pregnancy (OR = 1.13, 95% CI: 1.06, 1.21; I2 = 8%, P = 0.0001; N = 8).
CONCLUSIONS: This study confirmed that endometriosis may elevate the risk of developing gestational hypertensive disorders. Raising awareness of this issue will help to identify effective strategies for screening and early diagnosis of hypertensive disorders in pregnancy.
METHODS: Relevant articles were searched from the Cochrane Library, PubMed, Scopus and Web of Science from inception up to December 2023. The full-text observational studies published in English that had a confirmed diagnosis of endometriosis were included. The case group included pregnant women diagnosed with endometriosis at any stage, while the control group consisted of pregnant women who had not been previously diagnosed with endometriosis. Two authors extracted and analyzed the data independently. Disagreements were reconciled by reviewing the full text by a third author. Endnote X9 was used for screening and data extraction. We used fixed and random effects models in Review Manager 5.3 to analyze the pooled data. The quality of the included studies was assessed using the Downs and Black checklist.
RESULTS: Out of the 9863 articles reviewed, 23 were selected for meta-analysis. According to the results of this study, there was an association between endometriosis and gestational hypertension (OR = 1.11, 95% CI: 1.06, 1.16; I2 = 45%, P < 0.00001; N = 8), pre-eclampsia (OR = 1.26, 95% CI: 1.18, 1.36; I2 = 37%, P < 0.00001; N = 12), and hypertensive disorders in pregnancy (OR = 1.13, 95% CI: 1.06, 1.21; I2 = 8%, P = 0.0001; N = 8).
CONCLUSIONS: This study confirmed that endometriosis may elevate the risk of developing gestational hypertensive disorders. Raising awareness of this issue will help to identify effective strategies for screening and early diagnosis of hypertensive disorders in pregnancy.
摘要：
背景：子宫内膜异位症是一种慢性和使人衰弱的疾病，可影响女性的整个生殖生命过程，对怀孕有潜在的不良影响。本研究的目的是研究妊娠期高血压疾病与子宫内膜异位症之间的关系。
方法：从Cochrane图书馆搜索相关文章，PubMed,Scopus和WebofScience从成立到2023年12月。纳入了以英文发表的经证实诊断为子宫内膜异位症的全文观察性研究。病例组包括在任何阶段诊断为子宫内膜异位症的孕妇，而对照组包括先前未被诊断为子宫内膜异位症的孕妇。两位作者独立提取并分析了数据。第三作者通过审查全文来调和分歧。尾注X9用于筛选和数据提取。我们在ReviewManager5.3中使用了固定和随机效应模型来分析合并数据。使用Downs和Black检查表评估纳入研究的质量。
结果：在回顾的9863篇文章中，选择23人进行荟萃分析。根据这项研究的结果,子宫内膜异位症与妊娠期高血压有相关性(OR=1.11,95%CI:1.06,1.16;I2=45%,P<0.00001;N=8),先兆子痫（OR=1.26，95%CI：1.18，1.36；I2=37%，P<0.00001;N=12),和妊娠期高血压疾病（OR=1.13，95％CI：1.06，1.21;I2=8％，P=0.0001;N=8)。
结论：这项研究证实子宫内膜异位症可能会增加发生妊娠期高血压疾病的风险。提高对这一问题的认识将有助于确定妊娠期高血压疾病筛查和早期诊断的有效策略。
方法：从Cochrane图书馆搜索相关文章，PubMed,Scopus和WebofScience从成立到2023年12月。纳入了以英文发表的经证实诊断为子宫内膜异位症的全文观察性研究。病例组包括在任何阶段诊断为子宫内膜异位症的孕妇，而对照组包括先前未被诊断为子宫内膜异位症的孕妇。两位作者独立提取并分析了数据。第三作者通过审查全文来调和分歧。尾注X9用于筛选和数据提取。我们在ReviewManager5.3中使用了固定和随机效应模型来分析合并数据。使用Downs和Black检查表评估纳入研究的质量。
结果：在回顾的9863篇文章中，选择23人进行荟萃分析。根据这项研究的结果,子宫内膜异位症与妊娠期高血压有相关性(OR=1.11,95%CI:1.06,1.16;I2=45%,P<0.00001;N=8),先兆子痫（OR=1.26，95%CI：1.18，1.36；I2=37%，P<0.00001;N=12),和妊娠期高血压疾病（OR=1.13，95％CI：1.06，1.21;I2=8％，P=0.0001;N=8)。
结论：这项研究证实子宫内膜异位症可能会增加发生妊娠期高血压疾病的风险。提高对这一问题的认识将有助于确定妊娠期高血压疾病筛查和早期诊断的有效策略。
