PDF(Pubmed)
Abstract：
The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated secretory phenotypes (SASPs). Unfortunately, immunosenescence, a progressively dysregulated immunity with age, hampers effective SNC elimination, leading to accumulation, coupled with the release of SASPs, which, in turn, inhibits immunity and heightened susceptibility to aging-associated diseases (AADs). Natural killer (NK) cells, integral to the innate immune system, play a pivotal role in addressing SNCs swiftly. These cells also coordinate with other components of both innate and adaptive immunity to surveil and eliminate these cells. Accordingly, preserving NK cell function during aging is crucial for evading AADs and promoting healthy aging. Alternatively, NK-cell-based therapies present promising avenues for addressing the challenges associated with aging. Notable, recent studies in adoptive NK cell therapy have shown promise in rejuvenating immunosenescence, eliminating SNCs, and alleviating SASPs. This progress provides the proof-concept of adoptive NK cell therapy for senotherapy and holds promise as an emerging revolution in longevity therapeutics.
摘要：
衰老过程错综复杂地涉及免疫系统动力学，在管理衰老细胞（SNCs）及其衰老相关分泌表型（SASPs）方面具有关键作用。不幸的是,免疫衰老，随着年龄的增长，免疫力逐渐失调，阻碍有效的SNC消除，导致积累，再加上SASPs的发布，which,反过来,抑制免疫力和增加对衰老相关疾病（AAD）的易感性。自然杀伤（NK）细胞，先天免疫系统的组成部分，在迅速解决SNCs方面发挥着关键作用。这些细胞还与先天免疫和适应性免疫的其他成分协调以监视和消除这些细胞。因此，在衰老过程中保持NK细胞功能对于逃避AAD和促进健康衰老至关重要。或者，基于NK细胞的疗法为解决与衰老相关的挑战提供了有希望的途径。值得注意的,最近在过继NK细胞疗法的研究显示了恢复免疫衰老的前景，消除SNCs，减轻SASPs。这一进展为过继NK细胞疗法提供了证据概念，并有望成为长寿疗法的新兴革命。
