关键词: Parkinson’s disease Ser40 phosphorylation dopamine levodopa phosphodiesterase tyrosine hydroxylase

来  源:   DOI:10.1016/j.molmed.2024.06.002

Abstract:
Innovative therapeutic strategies are urgently needed for Parkinson\'s disease due to limited efficacy of current treatments and a weak therapeutic pipeline. In this forum article, we propose targeting tyrosine hydroxylase phosphorylation as a novel mechanism of action to address this critical need.
摘要:
由于目前治疗的疗效有限和治疗管道薄弱,因此帕金森病迫切需要创新的治疗策略。在这篇论坛文章中,我们建议将酪氨酸羟化酶磷酸化作为一种新的作用机制来解决这一关键需求。
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