Abstract：
We previously reported that a high HbA1c level 3 months before vitrectomy for vitreous hemorrhage or a large preoperative decrease in the HbA1c level over 3 months tended to increase the risk of rebleeding in diabetic retinopathy patients evaluated between 2010 and 2014. Here, we aimed to confirm these results with an extended study period and an increased number of operated eyes. This study included 121 diabetic patients who were admitted to Osaka University Hospital between 2010 and 2019 and who underwent vitrectomy for vitreous hemorrhage. Binomial logistic regression analysis was performed with the presence of postoperative bleeding as the outcome. The present study showed that the duration of the operation was associated with rebleeding (odds ratio = 1.02, p = 0.0016). A high HbA1c level just before vitrectomy tended to be associated with the bleeding (odds ratio = 1.27, p = 0.05), while preoperative HbA1c changes were not associated with rebleeding. The results of this study suggest that a high preoperative HbA1c level just before vitrectomy, not a decrease in HbA1c levels, in addition to the duration of the operation may increase the risk of postoperative bleeding after vitrectomy in diabetic retinopathy patients.
摘要：
我们先前报道，在2010年至2014年期间评估的玻璃体切除术治疗玻璃体出血前3个月的高HbA1c水平或术前3个月的HbA1c水平大幅下降倾向于增加糖尿病视网膜病变患者的再出血风险。这里,我们旨在通过延长研究时间和增加手术眼的数量来证实这些结果.这项研究包括2010年至2019年在大阪大学医院住院并接受玻璃体切除术治疗玻璃体出血的121名糖尿病患者。以术后出血为结果进行二项logistic回归分析。本研究表明，手术持续时间与再出血有关（比值比=1.02，p=0.0016）。玻璃体切除术前的高HbA1c水平倾向于与出血相关（比值比=1.27，p=0.05），而术前HbA1c变化与再出血无关。这项研究的结果表明，术前HbA1c水平高，HbA1c水平没有下降，除了手术持续时间可能增加糖尿病视网膜病变患者玻璃体切除术后出血的风险.
