Abstract：
The primary objective of this study was to identify predictors for biochemical recurrence (BCR) within 2 years following robot-assisted radical prostatectomy (RARP). Identifying predictors will enable insights that enhance personalized patient management and facilitate the ongoing refinement of postoperative therapy strategies.
This retrospective study included patients undergoing RARP from September 2014 to January 2021. Exclusion criteria were preoperative endocrine therapy, BCR beyond 2 years post-surgery, and incomplete postoperative data. Multivariate analyses were conducted to evaluate predictors of BCR, focusing on preoperative prostate-specific antigen (PSA) level, pathological tumor (pT) stage, Gleason score (GS), extraprostatic extension (EPE), and surgical margin status.
Among 374 patients, 40 experienced BCR within 2 years. Significant predictors of early BCR included initial PSA level ≥10 ng/ml, pT3 or greater, GS ≥8, EPE, and positive surgical margins (RM1). Multivariate analysis identified pT3 or higher, GS ≥8, and RM1 as independent risk factors for early BCR.
Early BCR after RARP is significantly associated with advanced pathological stage, high GS, and positive surgical margins. These findings emphasize the need for tailored postoperative management strategies and highlight the importance of precision in surgical technique to improve patient outcomes.
This retrospective study included patients undergoing RARP from September 2014 to January 2021. Exclusion criteria were preoperative endocrine therapy, BCR beyond 2 years post-surgery, and incomplete postoperative data. Multivariate analyses were conducted to evaluate predictors of BCR, focusing on preoperative prostate-specific antigen (PSA) level, pathological tumor (pT) stage, Gleason score (GS), extraprostatic extension (EPE), and surgical margin status.
Among 374 patients, 40 experienced BCR within 2 years. Significant predictors of early BCR included initial PSA level ≥10 ng/ml, pT3 or greater, GS ≥8, EPE, and positive surgical margins (RM1). Multivariate analysis identified pT3 or higher, GS ≥8, and RM1 as independent risk factors for early BCR.
Early BCR after RARP is significantly associated with advanced pathological stage, high GS, and positive surgical margins. These findings emphasize the need for tailored postoperative management strategies and highlight the importance of precision in surgical technique to improve patient outcomes.
摘要：
目的：本研究的主要目的是确定机器人辅助前列腺癌根治术（RARP）后2年内生化复发（BCR）的预测因子。确定预测因素将有助于提高个性化患者管理并促进术后治疗策略的持续完善。
方法：这项回顾性研究包括2014年9月至2021年1月接受RARP的患者。排除标准为术前内分泌治疗,手术后超过2年的BCR，和不完整的术后数据。进行多变量分析以评估BCR的预测因子，关注术前前列腺特异性抗原（PSA）水平，病理肿瘤(pT)分期,格里森评分（GS），前列腺外延伸（EPE），和手术边缘状态。
结果：在374名患者中，在2年内有40个BCR经验。早期BCR的重要预测因素包括初始PSA水平≥10ng/ml，pT3或更高，GS≥8,EPE,和阳性手术切缘（RM1）。多变量分析确定pT3或更高，GS≥8和RM1是早期BCR的独立危险因素。
结论：RARP术后早期BCR与晚期病理分期显著相关，高GS,和阳性手术切缘。这些发现强调了需要量身定制的术后管理策略，并强调了精确手术技术对改善患者预后的重要性。
方法：这项回顾性研究包括2014年9月至2021年1月接受RARP的患者。排除标准为术前内分泌治疗,手术后超过2年的BCR，和不完整的术后数据。进行多变量分析以评估BCR的预测因子，关注术前前列腺特异性抗原（PSA）水平，病理肿瘤(pT)分期,格里森评分（GS），前列腺外延伸（EPE），和手术边缘状态。
结果：在374名患者中，在2年内有40个BCR经验。早期BCR的重要预测因素包括初始PSA水平≥10ng/ml，pT3或更高，GS≥8,EPE,和阳性手术切缘（RM1）。多变量分析确定pT3或更高，GS≥8和RM1是早期BCR的独立危险因素。
结论：RARP术后早期BCR与晚期病理分期显著相关，高GS,和阳性手术切缘。这些发现强调了需要量身定制的术后管理策略，并强调了精确手术技术对改善患者预后的重要性。
