Abstract：
OBJECTIVE: Cysteine protease caspase-1 (Casp1) plays a crucial role in the conversion of pro-cytokines to active cytokines (CYTs). The purpose of this work was to determine Casp1 blood levels in a cohort of 114 cholecystectomy patients and assess their association with other CYTs and numeric rating scale (NRS) pain scores, postoperatively.
METHODS: Blood levels of Casp1 and seven CYTs (IL-18, IL-18BP, IL-1ra, IL-6, IL-10, IL-1β, and IL-8) were measured at three time points; before operation, immediately after operation, and six hours after operation in 114 patients with cholelithiasis (Chole).
RESULTS: Casp1 blood levels correlated with NRS pain scores at 24 h following surgery (p=0.016). In addition, Casp1 blood levels correlated significantly to IL-18 blood levels (p<0.001).
CONCLUSIONS: This is the first report to evaluate Casp1 blood levels in Chole patients in correlation with other CYTs. The findings confirm a significant correlation between Casp1 blood levels and NRS pain scores. Moreover, this study provides initial evidence suggesting that inhibition of the activity of Casp1 may reduce postsurgical acute phase immune response possibly through the Casp1/pro-Il-18 pathway.
METHODS: Blood levels of Casp1 and seven CYTs (IL-18, IL-18BP, IL-1ra, IL-6, IL-10, IL-1β, and IL-8) were measured at three time points; before operation, immediately after operation, and six hours after operation in 114 patients with cholelithiasis (Chole).
RESULTS: Casp1 blood levels correlated with NRS pain scores at 24 h following surgery (p=0.016). In addition, Casp1 blood levels correlated significantly to IL-18 blood levels (p<0.001).
CONCLUSIONS: This is the first report to evaluate Casp1 blood levels in Chole patients in correlation with other CYTs. The findings confirm a significant correlation between Casp1 blood levels and NRS pain scores. Moreover, this study provides initial evidence suggesting that inhibition of the activity of Casp1 may reduce postsurgical acute phase immune response possibly through the Casp1/pro-Il-18 pathway.
摘要：
目的：半胱氨酸蛋白酶caspase-1（Casp1）在前细胞因子向活性细胞因子（CYTs）的转化中起着至关重要的作用。这项工作的目的是确定114例胆囊切除术患者的Casp1血液水平，并评估其与其他CYT和数字评定量表（NRS）疼痛评分的关联。术后。
方法：Casp1和7个CYTs的血液水平（IL-18，IL-18BP，IL-1ra,IL-6，IL-10，IL-1β，和IL-8)在三个时间点进行测量；术前，手术后立即，114例胆石症（Chole）患者术后6小时。
结果：Casp1血液水平与术后24小时NRS疼痛评分相关（p=0.016）。此外,Caspl血液水平与IL-18血液水平显著相关(p<0.001)。
结论：这是第一份评估Chole患者Casp1血液水平与其他CYTs相关性的报告。这些发现证实了Casp1血液水平和NRS疼痛评分之间的显著相关性。此外，本研究提供了初步证据,提示抑制Casp1的活性可能通过Casp1/pro-Il-18途径降低术后急性期免疫应答.
方法：Casp1和7个CYTs的血液水平（IL-18，IL-18BP，IL-1ra,IL-6，IL-10，IL-1β，和IL-8)在三个时间点进行测量；术前，手术后立即，114例胆石症（Chole）患者术后6小时。
结果：Casp1血液水平与术后24小时NRS疼痛评分相关（p=0.016）。此外,Caspl血液水平与IL-18血液水平显著相关(p<0.001)。
结论：这是第一份评估Chole患者Casp1血液水平与其他CYTs相关性的报告。这些发现证实了Casp1血液水平和NRS疼痛评分之间的显著相关性。此外，本研究提供了初步证据,提示抑制Casp1的活性可能通过Casp1/pro-Il-18途径降低术后急性期免疫应答.
