关键词: Fertility preservation Gonadotoxic Sperm cryopreservation Testicular cancer survivorship

Mesh : Testicular Neoplasms / complications therapy Cancer Survivors Fertility Preservation Humans Male Cryopreservation Spermatozoa Infertility, Male / etiology

来  源:   DOI:10.1016/j.ucl.2024.03.011

Abstract:
Testicular cancer disproportionally affects men of reproductive age making fertility an important aspect of testicular cancer survivorship. Men with testicular cancer have more semen parameter abnormalities and a higher incidence of infertility compared to the general population. All treatment options for testicular cancer negatively affect fertility with recovery rates varying by treatment. For these reasons, clinicians should offer sperm cryopreservation, ideally before orchiectomy to maximize the possibility of biologic paternity, if desired. Several innovations have positively impacted this space including direct-to-consumer cryopreservation and bench research demonstrating the feasibility of reintroducing testicular cells post-therapy.
摘要:
睾丸癌不成比例地影响育龄男性,使生育能力成为睾丸癌生存的重要方面。与普通人群相比,患有睾丸癌的男性精液参数异常更多,不育的发生率更高。睾丸癌的所有治疗选择都会对生育能力产生负面影响,恢复率因治疗而异。由于这些原因,临床医生应该提供精子冷冻保存,理想的是在睾丸切除术前,以最大限度地提高生物亲子关系的可能性,如果需要的话。一些创新对这一领域产生了积极影响,包括直接面向消费者的冷冻保存和台式研究,证明了治疗后重新引入睾丸细胞的可行性。
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