Abstract：
This article reviews penile squamous cell carcinoma (PSCC), a rare genitourinary cancer that has been increasing in prevalence. It discusses emerging therapies, focusing on immunotherapy, vaccine therapy, and cell-based treatments, especially in the context of human papillomavirus-related PSCC. Factors influencing these therapies are discussed. These include the immune microenvironment, programmed cell death ligand-1 expression, and tumor immune cell infiltration. This article also highlights immune checkpoint inhibitors and related clinical trials. This review supports the use of personalized medicine in treating PSCC. It stresses the need for collaborative studies and data sharing to create specific treatment plans and achieve better outcomes.
摘要：
本文综述了阴茎鳞状细胞癌(PSCC),一种罕见的泌尿生殖系统癌症，患病率一直在增加。它讨论了新兴的疗法，专注于免疫疗法，疫苗治疗,和基于细胞的治疗，特别是在与人乳头瘤病毒相关的PSCC的背景下。讨论了影响这些疗法的因素。这些包括免疫微环境，程序性细胞死亡配体-1表达，和肿瘤免疫细胞浸润。本文还重点介绍了免疫检查点抑制剂和相关的临床试验。这篇综述支持个性化药物在治疗PSCC中的应用。它强调需要合作研究和数据共享，以制定具体的治疗计划并取得更好的结果。
