PDF(Pubmed)
Abstract：
BACKGROUND: While it is well recognised that aging is a heterogeneous process, our understanding of the determinants of biological aging and its heterogeneity remains unclear. The San Diego Nathan Shock Center (SD-NSC) Clinical Cohort aims to establish a resource of biospecimens and extensive donor clinical data such as physical, cognitive and sensory function to support other studies that aim to explore the heterogeneity of normal human aging and its biological underpinnings.
METHODS: The SD-NSC Clinical Cohort is composed of 80 individuals across the adult human lifespan. Strict inclusion and exclusion criteria are implemented to minimise extrinsic factors that may impede the study of normal aging. Across three visits, participants undergo extensive phenotyping for collection of physical performance, body composition, cognitive function, sensory ability, mental health and haematological data. During these visits, we also collected biospecimens including plasma, platelets, peripheral blood mononuclear cells and fibroblasts for banking and future studies on aging.
BACKGROUND: Ethics approval from the UC San Diego School of Medicine Institutional Review Board (IRB #201 141 SHOCK Center Clinical Cohort, PI: Molina) was obtained on 11 November 2020. Written informed consent is obtained from all participants after objectives and procedures of the study have been fully explained. Congruent with the goal of establishing a core resource, biological samples and clinical data are made available to the research community through the SD-NSC.
METHODS: The SD-NSC Clinical Cohort is composed of 80 individuals across the adult human lifespan. Strict inclusion and exclusion criteria are implemented to minimise extrinsic factors that may impede the study of normal aging. Across three visits, participants undergo extensive phenotyping for collection of physical performance, body composition, cognitive function, sensory ability, mental health and haematological data. During these visits, we also collected biospecimens including plasma, platelets, peripheral blood mononuclear cells and fibroblasts for banking and future studies on aging.
BACKGROUND: Ethics approval from the UC San Diego School of Medicine Institutional Review Board (IRB #201 141 SHOCK Center Clinical Cohort, PI: Molina) was obtained on 11 November 2020. Written informed consent is obtained from all participants after objectives and procedures of the study have been fully explained. Congruent with the goal of establishing a core resource, biological samples and clinical data are made available to the research community through the SD-NSC.
摘要：
背景：虽然人们公认老化是一个异质过程，我们对生物衰老的决定因素及其异质性的理解仍不清楚.圣地亚哥内森休克中心（SD-NSC）临床队列旨在建立生物标本和广泛的供体临床数据资源，如物理，认知和感觉功能，以支持其他旨在探索正常人衰老的异质性及其生物学基础的研究。
方法：SD-NSC临床队列由80个成年人组成。实施严格的纳入和排除标准，以尽量减少可能阻碍正常衰老研究的外在因素。在三次访问中，参与者进行广泛的表型分析，以收集身体表现，身体成分,认知功能,感官能力，心理健康和血液学数据。在这些访问期间,我们还收集了包括血浆在内的生物样本，血小板,外周血单核细胞和成纤维细胞用于储存和未来的衰老研究。
背景：来自加州大学圣地亚哥分校医学院机构审查委员会的道德批准（IRB#201141SHOCKCenter临床队列，PI：Molina）于2020年11月11日获得。在充分解释研究的目标和程序后，从所有参与者获得书面知情同意书。与建立核心资源的目标一致，生物样本和临床数据通过SD-NSC提供给研究界。
方法：SD-NSC临床队列由80个成年人组成。实施严格的纳入和排除标准，以尽量减少可能阻碍正常衰老研究的外在因素。在三次访问中，参与者进行广泛的表型分析，以收集身体表现，身体成分,认知功能,感官能力，心理健康和血液学数据。在这些访问期间,我们还收集了包括血浆在内的生物样本，血小板,外周血单核细胞和成纤维细胞用于储存和未来的衰老研究。
背景：来自加州大学圣地亚哥分校医学院机构审查委员会的道德批准（IRB#201141SHOCKCenter临床队列，PI：Molina）于2020年11月11日获得。在充分解释研究的目标和程序后，从所有参与者获得书面知情同意书。与建立核心资源的目标一致，生物样本和临床数据通过SD-NSC提供给研究界。
