Abstract：
MHC class I pathway consists of four main steps: proteasomal cleavage in the cytosol in which precursor proteins are cleaved into smaller peptides, which are then transported into the endoplasmic reticulum by the transporter associated with antigen processing, TAP, for further processing (trimming) from the N-terminal region by an ER resident aminopeptidases 1 (ERAP1) enzyme, to generate optimal peptides (8-10 amino acids in length) to produce a stable MHCI-peptide complex, that get transited via the Golgi apparatus to the cell surface for presentation to the cellular immune system. Several studies reported specificities related to the ERAP1 trimming process, yet there is no in silico tool for the prediction of the trimming process of the ERAP1 enzyme. In this paper, we provide and implement a prediction model for the trimming process of the ERAP1 enzyme.
摘要：
MHCI类途径由四个主要步骤组成：胞质溶胶中的蛋白酶体裂解，其中前体蛋白被裂解成较小的肽，然后通过与抗原加工相关的转运蛋白转运到内质网，TAP,用于由ER常驻氨肽酶1（ERAP1）酶从N末端区域进一步加工（修剪），生成最佳肽（长度为8-10个氨基酸）以产生稳定的MHCI-肽复合物，通过高尔基体转移到细胞表面，呈递给细胞免疫系统。一些研究报告了与ERAP1修剪过程相关的特异性，然而，还没有用于预测ERAP1酶的修剪过程的硅片工具。在本文中,我们提供并实现了ERAP1酶修剪过程的预测模型。
