Abstract:
During surge of COVID-19-associated mucormycosis (CAM), we identified five cases of CAM where two different species of Mucorales were isolated. All had history of diabetes mellitus and presented with clinical features suggesting rhino-orbital mucormycosis. The patients grew different species from their nasal scraping/biopsy samples, Rhizopus arrhizus, R. homothallicus (n = 2); R. homothallicus, Lictheimia corymbifera (n = 1); R. arrhizus, Mucor spp (n = 1); and L. corymbifera, Apophysomyces variabilis (n = 1). All patients underwent surgical and medical (liposomal amphotericin B) treatment. All, except one growing A. variabilis and L. corymbifera survived. Mixed infection by more than one Mucorales in CAM is unique and warrants epidemiological investigation.
摘要:
在COVID-19相关毛霉菌病(CAM)激增期间,我们确定了5例CAM,其中分离了两种不同的Mucorales。所有患者均有糖尿病史,临床特征提示鼻眶毛霉菌病。患者从鼻腔刮擦/活检样本中生长出不同的物种,阿耳根霉,R.同型(n=2);R.同型,紫草毛(n=1);arrhizus,毛霉属(n=1);和L.Corymbifera,变形杆菌(n=1)。所有患者均接受手术和药物(脂质体两性霉素B)治疗。All,除了一个生长的变形杆菌和L.Corymbifera存活。CAM中不止一种Mucorales的混合感染是独特的,需要进行流行病学调查。