Abstract：
BACKGROUND: The study aims to validate the Whooley questions for screening postpartum depression in Chinese women in a community setting.
METHODS: The Whooley questions was translated into Chinese following Beaton\'s intercultural debugging guidelines. From December 1, 2020 to June 30, 2021, primary maternal and child health workers in Kaifu District and Changsha County in Changsha City recruited women aged 18 years or older who had recently given birth during home visits within seven days of discharge from hospital. Participants women completed the Whooley questions online and underwent a diagnostic interview for DSM-IV within 7 days of the visit. We evaluated Cronbach\'s alpha, split-half reliability, area under the ROC curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and optimal cut-off value of the Whooley questions.
RESULTS: Of the 3,004 eligible women, 1,862 completed the Whooley questions and diagnostic interviews. Sixty-two women (3.3%) were diagnosed with depressive disorders. The Cronbach\'s alpha coefficient was 0.64, the split-half reliability was 0.64. The optimal cut-off value was when at least one questions was answered \"yes\", with an AUC of 0.84 (SE=0.03, 95%CI 0.78-0.90, P<0.001), sensitivity of 0.77 (95%CI 0.65-0.87), specificity of 0.89 (95%CI 0.88-0.90), PPV of 0.20 (95%CI 0.15-0.25) and NPV of 0.99 (95%CI 0.98-1.00).
CONCLUSIONS: This study shows that the Chinese version of the Whooley questions is a reliable tool for screening postpartum depression in the community, but it may lead to many false positive cases.
METHODS: The Whooley questions was translated into Chinese following Beaton\'s intercultural debugging guidelines. From December 1, 2020 to June 30, 2021, primary maternal and child health workers in Kaifu District and Changsha County in Changsha City recruited women aged 18 years or older who had recently given birth during home visits within seven days of discharge from hospital. Participants women completed the Whooley questions online and underwent a diagnostic interview for DSM-IV within 7 days of the visit. We evaluated Cronbach\'s alpha, split-half reliability, area under the ROC curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and optimal cut-off value of the Whooley questions.
RESULTS: Of the 3,004 eligible women, 1,862 completed the Whooley questions and diagnostic interviews. Sixty-two women (3.3%) were diagnosed with depressive disorders. The Cronbach\'s alpha coefficient was 0.64, the split-half reliability was 0.64. The optimal cut-off value was when at least one questions was answered \"yes\", with an AUC of 0.84 (SE=0.03, 95%CI 0.78-0.90, P<0.001), sensitivity of 0.77 (95%CI 0.65-0.87), specificity of 0.89 (95%CI 0.88-0.90), PPV of 0.20 (95%CI 0.15-0.25) and NPV of 0.99 (95%CI 0.98-1.00).
CONCLUSIONS: This study shows that the Chinese version of the Whooley questions is a reliable tool for screening postpartum depression in the community, but it may lead to many false positive cases.
摘要：
背景：该研究旨在验证Wooley问题在社区环境中筛查中国女性产后抑郁症。
方法：按照Beaton的跨文化调试指南将Whooley问题翻译成中文。2020年12月1日至2021年6月30日,长沙市开福区、长沙县基层妇幼保健工作者在出院七天内进行家访时,招募了近期分娩的18岁及以上妇女。参与者妇女在线完成了Wooley问题，并在访问后7天内接受了DSM-IV的诊断性访谈。我们评估了克朗巴赫的阿尔法，半分割可靠性，ROC曲线下面积(AUC),灵敏度,特异性，阳性预测值(PPV)，负预测值(NPV)，和Wooley问题的最优截止值。
结果：在3,004名合格女性中，1,862人完成了Wooley问题和诊断性访谈。62名妇女（3.3％）被诊断患有抑郁症。Cronbach的α系数为0.64，分裂半可靠性为0.64。最佳截止值是当至少一个问题被回答为“是”时，AUC为0.84（SE=0.03，95CI0.78-0.90，P<0.001），灵敏度为0.77（95CI0.65-0.87），特异性为0.89（95CI0.88-0.90），PPV为0.20（95CI0.15-0.25），净现值为0.99（95CI0.98-1.00）。
结论：这项研究表明，Wooley问题的中文版是筛查社区产后抑郁症的可靠工具，但它可能会导致许多假阳性病例。
方法：按照Beaton的跨文化调试指南将Whooley问题翻译成中文。2020年12月1日至2021年6月30日,长沙市开福区、长沙县基层妇幼保健工作者在出院七天内进行家访时,招募了近期分娩的18岁及以上妇女。参与者妇女在线完成了Wooley问题，并在访问后7天内接受了DSM-IV的诊断性访谈。我们评估了克朗巴赫的阿尔法，半分割可靠性，ROC曲线下面积(AUC),灵敏度,特异性，阳性预测值(PPV)，负预测值(NPV)，和Wooley问题的最优截止值。
结果：在3,004名合格女性中，1,862人完成了Wooley问题和诊断性访谈。62名妇女（3.3％）被诊断患有抑郁症。Cronbach的α系数为0.64，分裂半可靠性为0.64。最佳截止值是当至少一个问题被回答为“是”时，AUC为0.84（SE=0.03，95CI0.78-0.90，P<0.001），灵敏度为0.77（95CI0.65-0.87），特异性为0.89（95CI0.88-0.90），PPV为0.20（95CI0.15-0.25），净现值为0.99（95CI0.98-1.00）。
结论：这项研究表明，Wooley问题的中文版是筛查社区产后抑郁症的可靠工具，但它可能会导致许多假阳性病例。
