Abstract：
The aim of this work is to determine the effect of upper-body high intensity interval training (HIIT) on cardiometabolic risks in individuals with chronic paraplegia. Twenty-seven individuals (14 females, 13 males, mean ± SD age: 46 ± 9 years) with chronic paraplegia (spinal cord injury between T2 and L5 >1-year post-injury) took part in a randomized controlled trial and were included in the final analysis. Participants in the HIIT group (n = 18) performed ∼30 min of arm crank exercise (60 s intervals at 80%-90% peak heart rate) four times per week, for 6 weeks. Participants in the control (CON) group (n = 9) were asked to maintain their habitual diet and physical activity patterns over the study period. Outcome measures were taken at baseline and follow-up. The primary outcome measures were fasting insulin, peak power output (PPO) and peak aerobic capacity ( V ̇ O 2 peak ${{\\dot{V}}_{{{{\\mathrm{O}}}_{\\mathrm{2}}}{\\mathrm{peak}}}}$ ). Secondary outcome measures included body composition, postprandial glycaemic control, fasting blood lipids, inflammatory biomarkers and resting blood pressure. Differences between groups were assessed by ANCOVA, using baseline values as a covariate. PPO was higher in the HIIT (101 W, 97-106) compared to the CON (90 W, 83-96) group at follow-up (P = 0.006). There were no differences in fasting insulin (P = 0.415) or relative V ̇ O 2 peak ${{\\dot{V}}_{{{{\\mathrm{O}}}_{\\mathrm{2}}}{\\mathrm{peak}}}}$ (P = 0.417). Postprandial Matsuda insulin sensitivity index (ISIMatsuda) was higher in the HIIT (5.42, 4.69-6.15) compared to the CON (3.75, 2.46-5.04) group at follow-up (P = 0.036). Six weeks of upper-body HIIT increased PPO and ISIMatsuda, with no other beneficial effect on cardiometabolic component risks in persons with chronic paraplegia. HIGHLIGHTS: What is the central question of this study? What is the effect of upper-body high intensity interval training (HIIT) on cardiometabolic component risks in individuals with chronic paraplegia? What is the main finding and its importance? Six weeks of upper-body HIIT increased PPO and improved insulin sensitivity, but had no beneficial effect on other cardiometabolic component risks in persons with chronic paraplegia. The large effect size observed for insulin sensitivity may be important in terms of reducing the risk of type-2 diabetes in this population.
摘要：
这项工作的目的是确定上身高强度间歇训练（HIIT）对慢性截瘫患者心脏代谢风险的影响。27个人（14名女性，13名男性，平均±SD年龄：46±9岁）患有慢性截瘫（脊髓损伤在T2和L5之间>损伤后1年）参加了一项随机对照试验，并纳入最终分析。HIIT组（n=18）的参与者每周四次进行~30分钟的手臂曲柄运动（以80％-90％的峰值心率为60s间隔），6周。对照（CON）组（n=9）的参与者被要求在研究期间保持其习惯性饮食和身体活动模式。在基线和随访时采取了结果措施。主要结局指标是空腹胰岛素，峰值功率输出(PPO)和峰值有氧能力(V^O2峰值${{\\dot{V}}_{{{{\\mathrm{O}}}_{\\mathrm{2}}}{\\mathrm{峰值}}}}$)。次要结果指标包括身体成分，餐后血糖控制，空腹血脂，炎症生物标志物和静息血压。组间差异通过ANCOVA评估，使用基线值作为协变量。PPO在HIIT中更高(101W，97-106）与CON（90W，83-96)组随访(P=0.006)。空腹胰岛素(P=0.415)或相对V²O2峰值${{\\dot{V}}_{{{{\\mathrm{O}}}_{\\mathrm{2}}}{\\mathrm{峰值}}}$(P=0.417)无差异。在随访时，HIIT组（5.42，4.69-6.15）的餐后松田胰岛素敏感性指数（ISICatsuda）高于CON组（3.75，2.46-5.04）（P=0.036）。六周的上身HIIT增加了PPO和ISIMatsuda，对慢性截瘫患者的心脏代谢成分风险没有其他有益影响。重点：这项研究的中心问题是什么？上身高强度间歇训练（HIIT）对慢性截瘫患者心脏代谢成分风险的影响是什么？主要发现及其重要性是什么？六周的上身HIIT增加了PPO并改善了胰岛素敏感性，但对慢性截瘫患者的其他心脏代谢成分风险没有有益影响。观察到的胰岛素敏感性的大效应大小对于降低该人群中2型糖尿病的风险可能很重要。
