Abstract：
Currently, challenges such as chemotherapy resistance, resulting from preoperative and postoperative chemotherapy, postoperative recurrence, and poor bone regeneration quality, are becoming increasingly prominent in osteosarcoma (OS) treatment. There is an urgent need to find more effective ways to address these issues. Ferroptosis is a novel form of iron-dependent programmed cell death, distinct from other forms of cell death. In this paper, we summarize how, through the three major defense systems of ferroptosis, not only can substances from traditional Chinese medicine, antitumor drugs, and nano-drug carriers induce ferroptosis in OS cells, but they can also be combined with immunotherapy, differentiation therapy, and other treatment modalities to significantly enhance chemotherapy sensitivity and inhibit tumor growth. Thus, ferroptosis holds great potential in treating OS, offering more choices and possibilities for future clinical interventions.
摘要：
目前,如化疗耐药等挑战，术前和术后化疗，术后复发,骨骼再生质量差，在骨肉瘤(OS)治疗中日益突出。迫切需要找到更有效的方法来解决这些问题。铁凋亡是铁依赖性程序性细胞死亡的一种新形式，不同于其他形式的细胞死亡。在本文中,我们总结一下，通过铁中毒的三大防御系统，不仅可以从中药物质，抗肿瘤药物，纳米药物载体诱导OS细胞铁凋亡，但它们也可以与免疫疗法结合使用，分化治疗,和其他治疗方式显着增强化疗敏感性并抑制肿瘤生长。因此，在治疗OS方面具有巨大的潜力，为未来的临床干预提供更多的选择和可能性。
