PDF(Pubmed)
Abstract：
BACKGROUND: Vitamins D, E, A, B, C, and Omega-3 play crucial roles in modulating inflammatory and oxidative stress pathways, both implicated in abdominal aortic aneurysm (AAA) development. Recent research has explored the potential impact of dietary supplements on AAA progression. The systematic review aims to assess interventional studies investigating the effects of various dietary supplements on the development and severity of abdominal aortic aneurysms.
METHODS: A systematic search using relevant keywords related to abdominal aortic aneurysm and dietary supplements was conducted across four databases (PubMed, Embase, Scopus, and Web of Science). Quality assessment for animal studies employed SYRCLE and the Cochrane Collaboration Risk of Bias Tool for randomized control trials. The study protocol is registered in PROSPERO under the registry code CRD42023455958.
RESULTS: Supplementation with Omega-3, Vitamins A, C, D, E, and the Vitamin B family exhibited positive effects in AAA progression. These supplements contributed to a reduction in AAA diameter, elastin degradation, inflammatory responses, and reactive oxygen species. Additional supplements such as Zinc, methionine, and phytoestrogen also played roles in mitigating AAA progression.
CONCLUSIONS: The findings of this study underscore the potential role of dietary supplements in the progression of AAA. Predominantly based on animal studies, the results indicate that these supplements can limit AAA progression, primarily evidenced by their ability to mitigate inflammatory processes and oxidative stress pathways.
METHODS: A systematic search using relevant keywords related to abdominal aortic aneurysm and dietary supplements was conducted across four databases (PubMed, Embase, Scopus, and Web of Science). Quality assessment for animal studies employed SYRCLE and the Cochrane Collaboration Risk of Bias Tool for randomized control trials. The study protocol is registered in PROSPERO under the registry code CRD42023455958.
RESULTS: Supplementation with Omega-3, Vitamins A, C, D, E, and the Vitamin B family exhibited positive effects in AAA progression. These supplements contributed to a reduction in AAA diameter, elastin degradation, inflammatory responses, and reactive oxygen species. Additional supplements such as Zinc, methionine, and phytoestrogen also played roles in mitigating AAA progression.
CONCLUSIONS: The findings of this study underscore the potential role of dietary supplements in the progression of AAA. Predominantly based on animal studies, the results indicate that these supplements can limit AAA progression, primarily evidenced by their ability to mitigate inflammatory processes and oxidative stress pathways.
摘要：
背景：维生素D，E,A,B,C,Omega-3在调节炎症和氧化应激途径中起着至关重要的作用，两者都与腹主动脉瘤（AAA）的发展有关。最近的研究探索了膳食补充剂对AAA进展的潜在影响。系统评价旨在评估各种膳食补充剂对腹主动脉瘤的发展和严重程度的影响的介入研究。
方法：在四个数据库（PubMed，Embase,Scopus,和WebofScience)。使用SYRCLE和Cochrane协作偏差风险工具进行随机对照试验的动物研究质量评估。该研究方案在PROSPERO中注册，注册代码为CRD42023455958。
结果：补充Omega-3，维生素A，C,D,E,维生素B家族在AAA进展中表现出积极作用。这些补充剂有助于减少AAA直径，弹性蛋白降解，炎症反应，和活性氧。其他补充剂，如锌，蛋氨酸,植物雌激素也在缓解AAA进展中发挥作用。
结论：本研究结果强调了膳食补充剂在AAA进展中的潜在作用。主要基于动物研究，结果表明，这些补充剂可以限制AAA的进展，主要由它们减轻炎症过程和氧化应激途径的能力证明。
方法：在四个数据库（PubMed，Embase,Scopus,和WebofScience)。使用SYRCLE和Cochrane协作偏差风险工具进行随机对照试验的动物研究质量评估。该研究方案在PROSPERO中注册，注册代码为CRD42023455958。
结果：补充Omega-3，维生素A，C,D,E,维生素B家族在AAA进展中表现出积极作用。这些补充剂有助于减少AAA直径，弹性蛋白降解，炎症反应，和活性氧。其他补充剂，如锌，蛋氨酸,植物雌激素也在缓解AAA进展中发挥作用。
结论：本研究结果强调了膳食补充剂在AAA进展中的潜在作用。主要基于动物研究，结果表明，这些补充剂可以限制AAA的进展，主要由它们减轻炎症过程和氧化应激途径的能力证明。
