Cardiovascular disease (CVD) is a significant reason for morbidity and mortality. Ursolic acid (UA) has been shown to play important biological roles in the fight against fat accumulation, oxidative stress, insulin resistance via insulin-like growth factor 1, cancer, muscle atrophy, obesity and inflammation responsible for CVD. A systematic review and meta-analysis were conducted up to February 2023; six articles were included in the study and eleven cardiometabolic risk factors were identified. The pooled effect size showed that UA supplementation (dosage range is 50.94 to 450 mg/day) didn\'t significantly change body weight, body mass index, waist circumference, body fat percentage, lean body mass, systolic blood pressure, diastolic blood pressure, fasting blood glucose, insulin, triglyceride, and high-density lipoprotein compared with control groups.
心血管疾病(CVD)是发病率和死亡率的重要原因。熊果酸(UA)已被证明在对抗脂肪积累的斗争中发挥重要的生物学作用,氧化应激,胰岛素抵抗通过胰岛素样生长因子1,癌症,肌肉萎缩,肥胖和炎症是CVD的原因。直到2023年2月进行了系统评价和荟萃分析;该研究包括六篇文章,并确定了11个心脏代谢危险因素。汇总效应大小显示,UA补充剂(剂量范围为50.94至450毫克/天)没有显着改变体重,身体质量指数,腰围,身体脂肪百分比,瘦体重,收缩压,舒张压,空腹血糖,胰岛素,甘油三酯,和高密度脂蛋白与对照组比较。