PDF(Pubmed)
Abstract：
IL33 plays an important role in cancer. However, the role of liver cancer remains unclear. Open-accessed data was obtained from the Cancer Genome Atlas, Xena, and TISCH databases. Different algorithms and R packages are used to perform various analyses. Here, in our comprehensive study on IL33 in HCC, we observed its differential expression across cancers, implicating its role in cancer development. The single-cell analysis highlighted its primary expression in endothelial cells, unveiling correlations within the HCC microenvironment. Also, the expression level of IL33 was correlated with patients survival, emphasizing its potential prognostic value. Biological enrichment analyses revealed associations with stem cell division, angiogenesis, and inflammatory response. IL33\'s impact on the immune microenvironment showcased correlations with diverse immune cells. Genomic features and drug sensitivity analyses provided insights into IL33\'s broader implications. In a pan-cancer context, IL33 emerged as a potential tumour-inhibitor, influencing immune-related molecules. This study significantly advances our understanding of IL33 in cancer biology. IL33 exhibited differential expression across cancers, particularly in endothelial cells within the HCC microenvironment. IL33 is correlated with the survival of HCC patients, indicating potential prognostic value and highlighting its broader implications in cancer biology.
摘要：
IL33在癌症中起重要作用。然而,肝癌的作用尚不清楚.开放访问的数据来自癌症基因组图谱，Xena,和TISCH数据库。使用不同的算法和R包来执行各种分析。这里,在我们对肝癌IL33的综合研究中，我们观察了它在不同癌症中的差异表达，暗示它在癌症发展中的作用。单细胞分析强调了其在内皮细胞中的主要表达，揭示HCC微环境中的相关性。此外，IL33的表达水平与患者生存率相关，强调其潜在的预后价值。生物富集分析显示与干细胞分裂有关，血管生成,和炎症反应。IL33对免疫微环境的影响显示出与多种免疫细胞的相关性。基因组特征和药物敏感性分析提供了对IL33更广泛意义的见解。在泛癌症的背景下，IL33是一种潜在的肿瘤抑制剂，影响免疫相关分子。这项研究极大地促进了我们对IL33在癌症生物学中的理解。IL33在癌症中表现出差异表达，特别是在HCC微环境中的内皮细胞中。IL33与肝癌患者的生存率相关，表明潜在的预后价值，并强调其在癌症生物学中的更广泛意义。
