Abstract：
Physiological processes within the human body are regulated in approximately 24-h cycles known as circadian rhythms, serving to adapt to environmental changes. Bone rhythms play pivotal roles in bone development, metabolism, mineralization, and remodeling processes. Bone rhythms exhibit cell specificity, and different cells in bone display various expressions of clock genes. Multiple environmental factors, including light, feeding, exercise, and temperature, affect bone diurnal rhythms through the sympathetic nervous system and various hormones. Disruptions in bone diurnal rhythms contribute to the onset of skeletal disorders such as osteoporosis, osteoarthritis and skeletal hypoplasia. Conversely, these bone diseases can be effectively treated when aimed at the circadian clock in bone cells, including the rhythmic expressions of clock genes and drug targets. In this review, we describe the unique circadian rhythms in physiological activities of various bone cells. Then we summarize the factors synchronizing the diurnal rhythms of bone with the underlying mechanisms. Based on the review, we aim to build an overall understanding of the diurnal rhythms in bone and summarize the new preventive and therapeutic strategies for bone disorders.
摘要：
人体内的生理过程在大约24小时的周期中被调节，称为昼夜节律。适应环境变化。骨节律在骨骼发育中起关键作用，新陈代谢，矿化,和重塑过程。骨节律表现出细胞特异性，骨骼中的不同细胞显示各种时钟基因的表达。多种环境因素,包括光,喂养,锻炼,和温度，通过交感神经系统和各种激素影响骨骼昼夜节律。骨骼昼夜节律的破坏有助于骨骼疾病的发作，例如骨质疏松症，骨关节炎和骨骼发育不全。相反，当针对骨细胞的昼夜节律时，这些骨骼疾病可以得到有效治疗，包括时钟基因和药物靶标的节律表达。在这次审查中,我们描述了各种骨细胞生理活动中独特的昼夜节律。然后，我们总结了使骨骼昼夜节律与潜在机制同步的因素。根据审查，我们旨在全面了解骨骼昼夜节律，并总结骨骼疾病的新预防和治疗策略。
