Abstract：
Parkinson\'s disease (PD) is the second most common neurodegenerative disorder. The primary pathological features of PD include the presence of α-synuclein aggregates and Lewy bodies, mitochondrial dysfunction, oxidative stress, and neuroinflammation. Recently, omega-3 fatty acids (ω-3 PUFAs) have been under investigation as a preventive and/or therapeutic strategy for PD, primarily owing to their antioxidant and anti-inflammatory properties. Therefore, the objective of this study was to conduct a systematic review of the literature, focusing on studies that assessed the effects of ω-3 PUFAs in rodent models mimicking human PD. The search was performed using the terms \"Parkinson\'s disease,\" \"fish oil,\" \"omega 3,\" \"docosahexaenoic acid,\" and \"eicosapentaenoic acid\" across databases PUBMED, Web of Science, Science Direct, Scielo, and Google Scholar. Following analysis based on predefined inclusion and exclusion criteria, 39 studies were included. Considering behavioral parameters, pathological markers of the disease, quantification of ω-3 PUFAs in the brain, as well as anti-inflammatory, antioxidant, and anti-apoptotic effects, it can be observed that ω-3 PUFAs exhibit a potential neuroprotective effect in PD. In summary, this systematic review presents significant scientific evidence regarding the effects and mechanisms underlying the neuroprotective properties of ω-3 PUFAs, offering valuable insights for the development of future clinical investigations.
摘要：
帕金森病(PD)是第二常见的神经退行性疾病。PD的主要病理特征包括α-突触核蛋白聚集体和路易体的存在，线粒体功能障碍，氧化应激，和神经炎症。最近,omega-3脂肪酸（ω-3PUFA）作为PD的预防和/或治疗策略一直在研究中，主要是由于它们的抗氧化和抗炎特性。因此,这项研究的目的是对文献进行系统的回顾，重点是评估ω-3PUFA在模仿人类PD的啮齿动物模型中的作用的研究。使用术语“帕金森氏病”进行搜索，\"\"鱼油,\"\"欧米茄3，\"\"二十二碳六烯酸，“和”二十碳五烯酸“跨数据库发布，WebofScience,科学直接，Scielo,谷歌学者。根据预定义的纳入和排除标准进行分析后，共纳入39项研究。考虑到行为参数，疾病的病理标志物，大脑中ω-3PUFA的定量，以及抗炎，抗氧化剂，和抗凋亡作用，可以观察到ω-3PUFA在PD中表现出潜在的神经保护作用。总之,这篇系统综述提供了关于ω-3PUFA神经保护特性的作用和机制的重要科学证据，为未来临床研究的发展提供有价值的见解。
