METHODS: Analysis entailed multivariate linear and logistic regression, generalized additive model, and smoothing curve fitting using resource from 2007 to 2010 National Health and Nutrition Examination Survey (NHANES). To ascertain robustness and consistency of this association across different demographic strata, we conducted rigorous subgroup analyses and interaction tests.
RESULTS: Among 3359 participants, those with elevated SII displayed higher total prostate-specific antigen (tPSA) levels, higher risk for PCa, and lower free/total PSA (f/t PSA) ratio. Specifically, each unit increase of log2 (SII) was associated with a 0.22 ng/mL increase in tPSA (β: 0.22, 95% confidence intervals [CI] 0.05-0.38), a 2.22% decline in f/t PSA ratio (β: -2.22, 95% CI -3.20 to -1.23), and a 52% increased odds of being at high risk for PCa (odds ratio [OR]: 1.52, 95% CI 1.13-2.04). People in the top quartile of log2 (SII) exhibited 0.55 ng/mL increased tPSA (β: 0.55, 95% CI 0.19-0.90), 4.39% reduced f/t PSA ratio (β: -4.39, 95% CI -6.50 to -2.27), and 168% increased odds of being at high risk for PCa (OR: 2.68, 95% CI 1.32-5.46) compared to those in the bottom quartile.
CONCLUSIONS: Systemic immune and inflammatory condition, as represented by SII, is independently and positively associated with tPSA levels and the risk for PCa, as well as independently and negatively associated with f/t PSA ratio among middle-aged and older US males. These findings may enhance the effectiveness of PCa screening in predicting positive biopsy results.
方法:分析需要多元线性和逻辑回归,广义加法模型,使用2007年至2010年国家健康和营养检查调查(NHANES)的资源进行平滑曲线拟合。为了确定这种关联在不同人口阶层之间的稳健性和一致性,我们进行了严格的亚组分析和交互作用测试.
结果:在3359名参与者中,SII升高的患者表现出更高的总前列腺特异性抗原(tPSA)水平,PCa的风险更高,和较低的游离/总PSA(f/tPSA)比率。具体来说,log2(SII)的每一单位增加与tPSA的0.22ng/mL增加相关(β:0.22,95%置信区间[CI]0.05-0.38),f/tPSA比下降2.22%(β:-2.22,95%CI-3.20至-1.23),患PCa高风险的几率增加52%(比值比[OR]:1.52,95%CI1.13-2.04)。log2(SII)前四分位数的人表现出0.55ng/mL的tPSA增加(β:0.55,95%CI0.19-0.90),f/tPSA比降低4.39%(β:-4.39,95%CI-6.50至-2.27),与下四分位数相比,患PCa高风险的可能性增加了168%(OR:2.68,95%CI1.32-5.46)。
结论:全身免疫和炎症状态,如SII所示,与tPSA水平和PCa风险独立且呈正相关,以及与美国中年和老年男性的f/tPSA比值呈独立和负相关。这些发现可能会增强PCa筛查在预测阳性活检结果方面的有效性。