Abstract：
OBJECTIVE: Both excessive intake of sodium and inadequate intake of potassium are associated with blood pressure elevation and subsequent increase in the risk of cardiovascular disease, which accounts for the largest number of deaths in China and worldwide. Low sodium salt, a mixture of mainly sodium chloride and potassium chloride, has shown its great potential as a promising population strategy for sodium intake reduction through multiple large-scale, multicenter, randomized controlled trials among populations including patients with cardiovascular disease, individuals with and without hypertension, older and younger adults, and men and women in China and other countries. This Guidelines aims to provide expert recommendations for promotion and use of low sodium salt in China, based on the current available scientific evidence regarding the effectiveness, safety, cost-effectiveness, and acceptability of low sodium salts in various population groups and different application scenarios. The suggestions to key stakeholders are also made.
METHODS: A working group, an expert review committee and an advisory committee were established to be responsible for formulating the guidelines\' scope and key questions to be addressed, for searching, synthesizing, and evaluating research evidence, proposing and reviewing the recommendations. The consensus on the final recommendations was reached using the GRADE grid method.
RESULTS: The working group summarized current available evidence of salt substitution regarding its effectiveness, safety, cost-effectiveness, acceptability, availability, suitability, etc. The Guidelines provided six recommendations advising different populations how to use low sodium salt, four recommendations on the application of low sodium salts in different scenarios, and five suggestions for key stakeholders to promote salt substitution.
CONCLUSIONS: The first evidence-based guidelines on promotion and use of low sodium salts covers all key questions in relevance and would play a critical role in prevention and control of hypertension and cardiovascular disease in China and worldwide.
METHODS: A working group, an expert review committee and an advisory committee were established to be responsible for formulating the guidelines\' scope and key questions to be addressed, for searching, synthesizing, and evaluating research evidence, proposing and reviewing the recommendations. The consensus on the final recommendations was reached using the GRADE grid method.
RESULTS: The working group summarized current available evidence of salt substitution regarding its effectiveness, safety, cost-effectiveness, acceptability, availability, suitability, etc. The Guidelines provided six recommendations advising different populations how to use low sodium salt, four recommendations on the application of low sodium salts in different scenarios, and five suggestions for key stakeholders to promote salt substitution.
CONCLUSIONS: The first evidence-based guidelines on promotion and use of low sodium salts covers all key questions in relevance and would play a critical role in prevention and control of hypertension and cardiovascular disease in China and worldwide.
摘要：
目的：钠摄入过多和钾摄入不足均与血压升高和随后心血管疾病风险增加有关。这是中国和全世界死亡人数最多的国家。低钠盐,主要由氯化钠和氯化钾组成的混合物，已显示出其巨大的潜力，作为一种有希望的人口战略，通过多个大规模减少钠的摄入量，多中心，在包括心血管疾病患者在内的人群中进行随机对照试验，有和没有高血压的人，老年人和年轻人，中国和其他国家的男性和女性。本指南旨在为低钠盐在中国的推广和使用提供专家建议。根据目前关于有效性的现有科学证据，安全,成本效益，以及低钠盐在不同人群和不同应用场景中的可接受性。还向关键利益相关者提出了建议。
方法：一个工作组，成立了一个专家审查委员会和一个咨询委员会，负责制定指南的范围和要解决的关键问题，为了搜索，合成，评估研究证据，提出和审查建议。使用GRADE网格方法就最终建议达成了共识。
结果：工作组总结了盐取代的有效性的现有证据，安全,成本效益，可接受性,可用性,适用性,等。该指南提供了六项建议，建议不同人群如何使用低钠盐，关于低钠盐在不同场景中应用的四个建议，以及对关键利益相关者促进盐替代的五点建议。
结论：关于推广和使用低钠盐的第一个循证指南涵盖了所有相关的关键问题，并将在中国和全世界的高血压和心血管疾病的预防和控制中发挥关键作用。
方法：一个工作组，成立了一个专家审查委员会和一个咨询委员会，负责制定指南的范围和要解决的关键问题，为了搜索，合成，评估研究证据，提出和审查建议。使用GRADE网格方法就最终建议达成了共识。
结果：工作组总结了盐取代的有效性的现有证据，安全,成本效益，可接受性,可用性,适用性,等。该指南提供了六项建议，建议不同人群如何使用低钠盐，关于低钠盐在不同场景中应用的四个建议，以及对关键利益相关者促进盐替代的五点建议。
结论：关于推广和使用低钠盐的第一个循证指南涵盖了所有相关的关键问题，并将在中国和全世界的高血压和心血管疾病的预防和控制中发挥关键作用。
