Abstract：
Paget\'s \"Seed and Soil\" theory, proposed in 1889, emphasizes the importance of the microenvironment where cancer cells grow in metastatic sites. Over a century later, this concept remains a cornerstone in comprehending cancer biology and devising treatment strategies. The \"Seed and Soil\" theory, which initially explained how cancer spreads to distant organs, now also applies to the tumor microenvironment (TME) within primary tumors. This theory emphasizes the critical interaction between cancer cells (\"seeds\") and their surrounding environment (\"soil\") and how this interaction affects both tumor progression within the primary site and at metastatic sites. An important point to note is that the characteristics of the TME are not static but dynamic, undergoing substantial changes during tumor progression and after treatment with therapeutic drugs. Cancer-associated fibroblasts (CAFs), recognized as the principal noncancerous cellular component within the TME, play multifaceted roles in tumor progression including promoting angiogenesis, remodeling the extracellular matrix, and regulating immune responses. In this comprehensive review, we focus on the findings regarding how the dynamics of CAFs contribute to cancer progression and drug sensitivity. Understanding the dynamics of CAFs could provide new insights into cancer pathology and lead to important advancements in cancer research and treatment.
摘要：
佩吉特的“种子和土壤”理论，1889年提出，强调了癌细胞在转移部位生长的微环境的重要性。一个多世纪后，这一概念仍然是理解癌症生物学和制定治疗策略的基石。“种子和土壤”理论，最初解释了癌症如何扩散到远处的器官，现在也适用于原发性肿瘤内的肿瘤微环境（TME）。该理论强调癌细胞（“种子”）与其周围环境（“土壤”）之间的关键相互作用，以及这种相互作用如何影响原发部位和转移部位的肿瘤进展。需要注意的重要一点是，TME的特性不是静态的，而是动态的，在肿瘤进展期间和治疗药物治疗后发生实质性变化。癌症相关成纤维细胞（CAFs），被认为是TME中主要的非癌细胞成分，在肿瘤进展中发挥多方面的作用，包括促进血管生成，重塑细胞外基质，和调节免疫反应。在这次全面审查中，我们关注的是CAFs动态如何促进癌症进展和药物敏感性的研究结果.了解CAFs的动力学可以为癌症病理学提供新的见解，并导致癌症研究和治疗的重要进展。
