Abstract：
The potential adverse health effects of antiperspirant use are of interest to patients, primary care providers, dermatologists, and pathologists. In rare instances, antiperspirants containing aluminum-zirconium complexes have been associated with granulomatous dermatoses despite being deemed non-sensitizing in experiments. In this case study, we present a detailed examination of an axillary granuloma in a 28-year-old female who had been using an aluminum-zirconium-based antiperspirant for several years and presented with a left axillary nodule that was excised and analyzed using scanning electron microscopy with energy-dispersive x-ray analysis (SEM/EDXA). Histopathological examination revealed a foreign body-type reaction with amphophilic granular material within giant cells that corresponded to collocated zirconium and aluminum on SEM/EDXA elemental maps. Our case adds to the limited reports of axillary granulomas related to aluminum-zirconium complexes. It illustrates the histopathological appearance and in situ distribution of the aluminum-zirconium complexes, supporting the formation of foreign body-type granulomas. Additionally, our case study illustrates the potential role of these compounds in such reactions and aims to increase awareness among pathologists and clinicians.
摘要：
使用止汗剂对健康的潜在不利影响是患者感兴趣的，初级保健提供者，皮肤科医生,和病理学家。在极少数情况下,尽管在实验中被认为不敏感，但含有铝-锆复合物的止汗剂与肉芽肿性皮肤病有关。在这个案例研究中,我们对一名28岁女性的腋窝肉芽肿进行了详细检查,该女性使用铝-锆基止汗剂已有数年,并出现左腋窝结节,该结节被切除,并使用扫描电镜和能量色散X线分析(SEM/EDXA)进行分析.组织病理学检查显示，巨细胞内的两性颗粒状物质与异物型反应，在SEM/EDXA元素图上对应于并置的锆和铝。我们的病例增加了与铝锆复合物相关的腋窝肉芽肿的报道。它说明了铝-锆配合物的组织病理学外观和原位分布，支持异物型肉芽肿的形成。此外,我们的案例研究说明了这些化合物在此类反应中的潜在作用，旨在提高病理学家和临床医生的认识。
