Abstract：
OBJECTIVE: To analyze the specificity of calcitonin gene-related peptide (CGRP) levels, we measured alpha-CGRP circulating levels in a large series of patients with a recent diagnosis of inflammatory bowel disease (IBD) who were interviewed regarding comorbid headache.
BACKGROUND: Several studies have found an association between migraine and IBD.
METHODS: In this cross-sectional study performed in an IBD clinic, morning serum alpha-CGRP levels were measured by enzyme-linked immunosorbent assay in 96 patients who were recently diagnosed with IBD and compared to those from 50 similar patients with chronic migraine (CM) and 50 healthy controls (HC).
RESULTS: Alpha-CGRP levels were higher in patients with IBD (median [interquartile range] 56.9 [35.6-73.9] pg/mL) and patients with CM (53.0 [36.7-73.9] pg/mL) compared to HC (37.2 [30.0-51.8] pg/mL; p = 0.003; p = 0.019, respectively). Regarding IBD diagnostic subtypes, alpha-CGRP levels for ulcerative colitis (67.2 ± 49.3 pg/mL; 57.0 [35.6-73.4] pg/mL) and Crohn\'s disease (54.9 ± 27.5 pg/mL; 57.7 [29.1-76.1] pg/mL) were significantly higher than those of HC (p = 0.013, p = 0.040, respectively). Alpha-CGRP levels were further different in patients with IBD with migraine (70.9 [51.8-88.7] pg/mL) compared to HC (p < 0.001), patients with IBD without headache (57.5 [33.3-73.8] pg/mL; p = 0.049), and patients with IBD with tension-type headache but without migraine (41.7 [28.5-66.9] pg/mL; p = 0.004), though alpha-CGRP levels in patients with IBD without migraine (53.7 [32.9-73.5] pg/mL) remained different over HC (p = 0.028).
CONCLUSIONS: Together with CM, circulating alpha-CGRP levels are different in patients with IBD, perhaps reflecting a chronic inflammatory state. IBD is an example of how alpha-CGRP levels are not a totally specific migraine biomarker. However, alpha-CGRP levels were further increased in patients with IBD who have a history of migraine, which reinforces its role as a biomarker in migraine patients, always bearing in mind their comorbidities.
BACKGROUND: Several studies have found an association between migraine and IBD.
METHODS: In this cross-sectional study performed in an IBD clinic, morning serum alpha-CGRP levels were measured by enzyme-linked immunosorbent assay in 96 patients who were recently diagnosed with IBD and compared to those from 50 similar patients with chronic migraine (CM) and 50 healthy controls (HC).
RESULTS: Alpha-CGRP levels were higher in patients with IBD (median [interquartile range] 56.9 [35.6-73.9] pg/mL) and patients with CM (53.0 [36.7-73.9] pg/mL) compared to HC (37.2 [30.0-51.8] pg/mL; p = 0.003; p = 0.019, respectively). Regarding IBD diagnostic subtypes, alpha-CGRP levels for ulcerative colitis (67.2 ± 49.3 pg/mL; 57.0 [35.6-73.4] pg/mL) and Crohn\'s disease (54.9 ± 27.5 pg/mL; 57.7 [29.1-76.1] pg/mL) were significantly higher than those of HC (p = 0.013, p = 0.040, respectively). Alpha-CGRP levels were further different in patients with IBD with migraine (70.9 [51.8-88.7] pg/mL) compared to HC (p < 0.001), patients with IBD without headache (57.5 [33.3-73.8] pg/mL; p = 0.049), and patients with IBD with tension-type headache but without migraine (41.7 [28.5-66.9] pg/mL; p = 0.004), though alpha-CGRP levels in patients with IBD without migraine (53.7 [32.9-73.5] pg/mL) remained different over HC (p = 0.028).
CONCLUSIONS: Together with CM, circulating alpha-CGRP levels are different in patients with IBD, perhaps reflecting a chronic inflammatory state. IBD is an example of how alpha-CGRP levels are not a totally specific migraine biomarker. However, alpha-CGRP levels were further increased in patients with IBD who have a history of migraine, which reinforces its role as a biomarker in migraine patients, always bearing in mind their comorbidities.
摘要：
目的:分析降钙素基因相关肽(CGRP)水平的特异性,我们测量了大量近期诊断为炎症性肠病(IBD)的患者的α-CGRP循环水平,这些患者接受了关于共病头痛的访谈.
背景：一些研究发现偏头痛与IBD之间存在关联。
方法：在IBD诊所进行的这项横断面研究中，本研究通过酶联免疫吸附试验测定了96例近期诊断为IBD的患者的早晨血清α-CGRP水平,并与50例类似慢性偏头痛(CM)患者和50例健康对照(HC)的患者进行了比较.
结果：与HC（37.2[30.0-51.8]pg/mL;p=0.003;p=0.019）相比，IBD患者（中位数[四分位数间距]56.9[35.6-73.9]pg/mL）和CM患者（53.0[36.7-73.9]pg/mL）的α-CGRP水平较高。关于IBD诊断亚型，溃疡性结肠炎(67.2±49.3pg/mL;57.0[35.6-73.4]pg/mL)和克罗恩病(54.9±27.5pg/mL;57.7[29.1-76.1]pg/mL)的α-CGRP水平显著高于HC(分别为p=0.013,p=0.040)。与HC（p<0.001）相比，IBD伴偏头痛患者的α-CGRP水平进一步不同（70.9[51.8-88.7]pg/mL），无头痛的IBD患者（57.5[33.3-73.8]pg/mL;p=0.049），和IBD患者伴有紧张型头痛但无偏头痛（41.7[28.5-66.9]pg/mL;p=0.004），尽管无偏头痛的IBD患者的α-CGRP水平（53.7[32.9-73.5]pg/mL）与HC（p=0.028）相比仍存在差异。
结论：与CM一起，IBD患者的循环α-CGRP水平不同，可能反映了慢性炎症状态.IBD是α-CGRP水平如何不是完全特异性偏头痛生物标志物的一个例子。然而,α-CGRP水平在有偏头痛病史的IBD患者中进一步升高，这加强了它作为偏头痛患者生物标志物的作用，始终牢记他们的合并症。
背景：一些研究发现偏头痛与IBD之间存在关联。
方法：在IBD诊所进行的这项横断面研究中，本研究通过酶联免疫吸附试验测定了96例近期诊断为IBD的患者的早晨血清α-CGRP水平,并与50例类似慢性偏头痛(CM)患者和50例健康对照(HC)的患者进行了比较.
结果：与HC（37.2[30.0-51.8]pg/mL;p=0.003;p=0.019）相比，IBD患者（中位数[四分位数间距]56.9[35.6-73.9]pg/mL）和CM患者（53.0[36.7-73.9]pg/mL）的α-CGRP水平较高。关于IBD诊断亚型，溃疡性结肠炎(67.2±49.3pg/mL;57.0[35.6-73.4]pg/mL)和克罗恩病(54.9±27.5pg/mL;57.7[29.1-76.1]pg/mL)的α-CGRP水平显著高于HC(分别为p=0.013,p=0.040)。与HC（p<0.001）相比，IBD伴偏头痛患者的α-CGRP水平进一步不同（70.9[51.8-88.7]pg/mL），无头痛的IBD患者（57.5[33.3-73.8]pg/mL;p=0.049），和IBD患者伴有紧张型头痛但无偏头痛（41.7[28.5-66.9]pg/mL;p=0.004），尽管无偏头痛的IBD患者的α-CGRP水平（53.7[32.9-73.5]pg/mL）与HC（p=0.028）相比仍存在差异。
结论：与CM一起，IBD患者的循环α-CGRP水平不同，可能反映了慢性炎症状态.IBD是α-CGRP水平如何不是完全特异性偏头痛生物标志物的一个例子。然而,α-CGRP水平在有偏头痛病史的IBD患者中进一步升高，这加强了它作为偏头痛患者生物标志物的作用，始终牢记他们的合并症。
