Abstract：
BACKGROUND: The identification of predictive parameters of the success of multidisciplinary weight loss interventions (MWLI) appears essential to optimize obesity management. The association between baseline cardiorespiratory fitness (CRF) and changes in anthropometric parameters and body composition during MWLI remains underexplored in adolescents with obesity.
OBJECTIVE: To assess whether baseline CRF was associated with the effectiveness of a 16-week MWLI measured through improved body mass, body mass index (BMI) and body composition (percentage of total fat mass (FM) as the main criterion).
METHODS: Cardiorespiratory fitness and body composition were respectively measured by peak oxygen consumption (VO2peak) during maximal exercise tests and dual-photon x-ray absorptiometry (DXA), before (T0) and after (T1) a 16-week MWLI in 165 adolescents (aged 13.3 ± 1.38 years, 61.2% female, BMI 35.11 ± 5.16 kg/m2).
RESULTS: Reductions in BMI and total FM percentage between T0 and T1 were greater in subjects with a baseline VO2peak ≥ 3rd quartile compared to the first quartile (p < 0.001) and the interquartile range (p < 0.05 and p < 0.001, respectively). Baseline VO2peak and VO2 at the first ventilator threshold were positively correlated with the reductions in body mass, BMI and total and visceral FM percentages and with the increase in lean mass (LM) percentage between T0 and T1 after adjustment for age and gender (p < 0.001).
CONCLUSIONS: Initial CRF is associated with the success of MWLI in adolescents with obesity. Improving their aerobic fitness before starting a MWLI might be a promising strategy to optimize its benefits.
OBJECTIVE: To assess whether baseline CRF was associated with the effectiveness of a 16-week MWLI measured through improved body mass, body mass index (BMI) and body composition (percentage of total fat mass (FM) as the main criterion).
METHODS: Cardiorespiratory fitness and body composition were respectively measured by peak oxygen consumption (VO2peak) during maximal exercise tests and dual-photon x-ray absorptiometry (DXA), before (T0) and after (T1) a 16-week MWLI in 165 adolescents (aged 13.3 ± 1.38 years, 61.2% female, BMI 35.11 ± 5.16 kg/m2).
RESULTS: Reductions in BMI and total FM percentage between T0 and T1 were greater in subjects with a baseline VO2peak ≥ 3rd quartile compared to the first quartile (p < 0.001) and the interquartile range (p < 0.05 and p < 0.001, respectively). Baseline VO2peak and VO2 at the first ventilator threshold were positively correlated with the reductions in body mass, BMI and total and visceral FM percentages and with the increase in lean mass (LM) percentage between T0 and T1 after adjustment for age and gender (p < 0.001).
CONCLUSIONS: Initial CRF is associated with the success of MWLI in adolescents with obesity. Improving their aerobic fitness before starting a MWLI might be a promising strategy to optimize its benefits.
摘要：
背景：确定多学科减肥干预（MWLI）成功的预测参数似乎对于优化肥胖管理至关重要。在肥胖青少年中，MWLI期间基线心肺适应性（CRF）与人体测量参数和身体成分变化之间的关联仍未得到充分研究。
目的：为了评估基线CRF是否与通过改善体重测量的16周MWLI的有效性相关，体重指数（BMI）和身体成分（占总脂肪量的百分比（FM）为主要标准）。
方法：在最大运动测试和双光子X射线吸收法（DXA）期间，分别通过峰值耗氧量（VO2peak）测量心肺适应性和身体成分，在165名青少年（年龄13.3±1.38岁，61.2%女性，BMI35.11±5.16kg/m2)。
结果：与第一四分位数（p<0.001）和四分位数范围（分别为p<0.05和p<0.001）相比，基线VO2峰≥第三四分位数的受试者在T0和T1之间的BMI和总FM百分比降低更大。基线VO2peak和第一呼吸机阈值处的VO2与体重的减少呈正相关。调整年龄和性别后，BMI和总和内脏FM百分比以及T0和T1之间瘦体重（LM）百分比的增加（p<0.001）。
结论：初始CRF与肥胖青少年MWLI的成功相关。在开始MWLI之前改善他们的有氧健身可能是优化其益处的有希望的策略。
目的：为了评估基线CRF是否与通过改善体重测量的16周MWLI的有效性相关，体重指数（BMI）和身体成分（占总脂肪量的百分比（FM）为主要标准）。
方法：在最大运动测试和双光子X射线吸收法（DXA）期间，分别通过峰值耗氧量（VO2peak）测量心肺适应性和身体成分，在165名青少年（年龄13.3±1.38岁，61.2%女性，BMI35.11±5.16kg/m2)。
结果：与第一四分位数（p<0.001）和四分位数范围（分别为p<0.05和p<0.001）相比，基线VO2峰≥第三四分位数的受试者在T0和T1之间的BMI和总FM百分比降低更大。基线VO2peak和第一呼吸机阈值处的VO2与体重的减少呈正相关。调整年龄和性别后，BMI和总和内脏FM百分比以及T0和T1之间瘦体重（LM）百分比的增加（p<0.001）。
结论：初始CRF与肥胖青少年MWLI的成功相关。在开始MWLI之前改善他们的有氧健身可能是优化其益处的有希望的策略。
