Abstract：
Lysergic acid diethylamide (LSD) analogs have emerged as new psychoactive substances (NPS) since the mid-2010s, and new compounds continue to emerge for recreational use. Since the end of 2023, \"1D-AL-LAD\" appeared on X (formerly Twitter) and other websites. As for the compound \"1D-LSD\" (which also has \"1D\" in the name), several studies show that the ingredient of seized blotter paper printed \"1D-LSD\" was actually 1-(2-thienoyl)-LSD (1T-LSD). However, there are no reports of seizures of 1-(1,2-dimethylcyclobutanecarbonyl)-LSD (1D-LSD). Accordingly, it was considered that all or at least a certain percentage of \"1D-AL-LAD (1-(1,2-dimethylcyclobutanecarbonyl)-6-allyl-nor-LSD)\" is actually 1-(2-thienoyl)-6-allyl-nor-LSD (1T-AL-LAD). This compound is handled by a number of distributors as of April 2024; therefore, it should be characterized in advance if seized. In this study, 1T-AL-LAD was synthesized and characterized using nuclear magnetic resonance spectroscopy, Fourier transform-infrared spectroscopy, liquid chromatography/high-resolution mass spectrometry (LC/HRMS) and gas chromatography/MS (GC/MS). This compound was easily distinguished from previously reported lysergamides. There were some differences in the detectability of 1T-AL-LAD compared with other lysergamides using GC/MS and the fragmentation patterns in LC/HRMS. These differences can be reasonably explained. This information will be of help to determine this substance in seized materials should it emerge on the market.
摘要：
自2010年代中期以来，麦角酸二乙酰胺（LSD）类似物已成为新的精神活性物质（NPS），新的化合物继续出现用于娱乐用途。自2023年底以来，“1D-AL-LAD”出现在X（以前的Twitter）和其他网站上。至于化合物“1D-LSD”(名称中也有“1D”)，多项研究表明，查获的印有“1D-LSD”的吸墨纸的成分实际上是1-（2-噻吩酰基）-LSD（1T-LSD）。然而,目前尚无1-(1,2-二甲基环丁烷羰基)-LSD(1D-LSD)癫痫发作的报告.因此，认为所有或至少一定百分比的“1D-AL-LAD（1-（1,2-二甲基环丁烷羰基）-6-烯丙基-nor-LSD）”实际上是1-（2-噻吩酰基）-6-烯丙基-nor-LSD（1T-AL-LAD）。截至2024年4月，该化合物由许多分销商处理；因此，如果被扣押，它应该事先被定性。在这项研究中,合成了1T-AL-LAD，并使用核磁共振波谱对其进行了表征，傅里叶变换红外光谱,液相色谱/高分辨质谱(LC/HRMS)和气相色谱/MS(GC/MS)。该化合物很容易与先前报道的lysergamides区分开。使用GC/MS和LC/HRMS中的裂解模式与其他lysergyides相比，1T-AL-LAD的可检测性存在一些差异。这些差异是可以合理解释的。如果市场上出现这种物质，这些信息将有助于确定缉获材料中的这种物质。
