Abstract：
Atrazine is a triazine organochloride herbicide, frequently used in different agricultural activities. Rare acute intoxication with atrazine is reported in production animals, and its metabolism in mammals is unknown. We report a spontaneous case of atrazine acute intoxication in 16.1% animals of a 168-beef heifer herd exposed to the herbicide at a farm located in Buenos Aires province, Argentina. Affected heifers showed different neurological signs and died suddenly, similar to the previous natural atrazine intoxication report. During autopsy, no gross lesions were observed. Different body fluids and tissues samples were collected during postmortem examination. No relevant histopathological findings were observed. High levels of atrazine and its metabolites were detected in different fluids and tissues by ultra-liquid chromatography high performance coupled to triple quadrupole mass spectrometry. These findings suggest ruminal or hepatic metabolization of atrazine in the exposed cattle. This is the first report of quantification and distribution of atrazine and its metabolites in intoxicated mammals providing relevant information for diagnostic purposes.
摘要：
阿特拉津是一种三嗪有机氯化物除草剂，经常用于不同的农业活动。据报道，生产动物中出现了罕见的阿特拉津急性中毒，它在哺乳动物中的代谢是未知的。我们报告了在位于布宜诺斯艾利斯省的一个农场中，暴露于除草剂的168只牛肉小母牛群的16.1％动物中的阿特拉津急性中毒的自发病例。阿根廷。受影响的小母牛表现出不同的神经系统症状，突然死亡，类似于之前的天然阿特拉津中毒报告。在尸检期间,未观察到大体病变。在验尸过程中收集了不同的体液和组织样本。没有观察到相关的组织病理学发现。通过超液相色谱高效耦合三重四极杆质谱，在不同的流体和组织中检测到高水平的阿特拉津及其代谢物。这些发现表明，在暴露的牛中，阿特拉津的瘤胃或肝脏代谢。这是有关中毒哺乳动物中阿特拉津及其代谢物的定量和分布的第一份报告，为诊断目的提供了相关信息。
