Abstract：
Both prokaryotic and eukaryotic organisms use the nucleotide-binding domain/leucine-rich repeat (NBD/LRR)-triggered immunity (NLR-triggered immunity) signaling pathway to defend against pathogens. Plant NLRs are intracellular immune receptors that can bind to effector proteins secreted by pathogens. Dicotyledonous plants express a type of NLR known as TIR domain-containing NLRs (TNLs). TIR domains are enzymes that catalyze the production of small molecules that are essential for immune signaling and lead to plant cell death. The activation of downstream TNL signaling components, such as enhanced disease susceptibility 1 (EDS1), phytoalexin deficient 4 (PAD4), and senescence-associated gene 101 (SAG101), is facilitated by these small molecules. Helper NLRs (hNLRs) and the EDS1-PAD4/SAG101 complex associate after activation, causing the hNLRs to oligomerize, translocate to the plasma membrane (PM), and produce cation-selective channels. According to a recent theory, cations enter cells through pores created by oligomeric hNLRs and trigger cell death. Occasionally, TNLs can self-associate to create higher-order oligomers. Here, we categorized soybean TNLs based on the protein domains that they possess. We believe that TNLs may help soybean plants effectively fight pathogens by acting as a source of genetic resistance. In summary, the purpose of this review is to elucidate the range of TNLs that are expressed in soybean.
摘要：
原核和真核生物都使用核苷酸结合域/富含亮氨酸重复序列（NBD/LRR）触发的免疫（NLR触发的免疫）信号通路来防御病原体。植物NLR是可以结合病原体分泌的效应蛋白的细胞内免疫受体。双子叶植物表达一种NLR,称为含有TIR结构域的NLR(TNL)。TIR结构域是催化小分子产生的酶,所述小分子对于免疫信号传导是必需的并导致植物细胞死亡。下游TNL信号传导组件的激活，如疾病易感性增强1（EDS1），植物抗毒素缺乏4（PAD4），和衰老相关基因101（SAG101），是由这些小分子促进的。辅助NLR（hNLR）和EDS1-PAD4/SAG101复合物在激活后缔合，导致hNLR寡聚化，易位到质膜（PM），并产生阳离子选择性通道。根据最近的理论，阳离子通过寡聚hNLR产生的孔进入细胞并引发细胞死亡。偶尔,TNL可以自缔合以产生更高阶的寡聚体。这里,我们根据大豆的蛋白质结构域对它们进行了分类。我们认为，TNL可以通过充当遗传抗性的来源来帮助大豆植物有效对抗病原体。总之,这篇综述的目的是阐明在大豆中表达的TNL的范围。
