Abstract：
The genus Flavivirus comprises approximately 80 different viruses. Phylogenetic relationships among its members indicate a clear ecological separation between those viruses transmitted by mosquitoes, ticks, with no known vector, and insect-specific Flaviviruses. The diversity and phylogenetic relationships among insect-specific flaviviruses circulating in the central and northern regions of Argentina were studied by performing molecular detection and characterization of the NS5 protein gene in mosquitoes collected in Córdoba, Chaco and Tucumán provinces. Overall, 68 out of 1776 pools were positive. CxFV, KRV and CFAV circulate in the 3 studied provinces. Several mosquito species (Aedes aegypti, Culex bidens, Cx. dolosus, Cx. interfor, Cx. quinquefasciatus, Cx. saltanensis, Haemagogus spegazzini) were found infected. A wide circulation of CxFV was observed in the central-northern region of Argentina. CxFV strains detected in our study clustered with strains circulating in Santa Fe and Buenos Aires provinces (Argentina), and other countries such as Indonesia, Mexico, Uganda and Taiwan. The presence of these viruses in mosquitoes could play an important role from the public health perspective, because it has been shown that previous CxFV infection can increase or block the infection of the mosquito by other pathogenic flaviviruses.
摘要：
黄病毒属包含大约80种不同的病毒。其成员之间的系统发育关系表明，蚊子传播的病毒之间存在明显的生态分离，蜱,没有已知的载体，和昆虫特异性黄病毒。通过对科尔多瓦收集的蚊子中的NS5蛋白基因进行分子检测和表征，研究了在阿根廷中部和北部地区传播的昆虫特异性黄病毒之间的多样性和系统发育关系，查科和图库曼省。总的来说,1776个池中有68个为阳性。CxFV,KRV和CFAV在3个研究省份中流通。几种蚊子（埃及伊蚊，Culexbidens,Cx.多洛索斯,Cx.interfor,Cx.Quinquefasciatus,Cx.saltanensis,Haemagogusspegazzini）被发现感染。在阿根廷的中北部地区观察到CxFV的广泛循环。在我们的研究中检测到的CxFV菌株与在圣达菲和布宜诺斯艾利斯省（阿根廷）传播的菌株聚集在一起，和其他国家，如印度尼西亚，墨西哥,乌干达和台湾。从公共卫生的角度来看，这些病毒在蚊子中的存在可以发挥重要作用，因为已经证明以前的CxFV感染可以增加或阻止其他致病性黄病毒对蚊子的感染。
