FAK 丢失减少 BRAFV600E 诱导的 ERK 磷酸化 , 促进肠干性和盲肠肿瘤形成。
关键词: BRAFV600E EGFR ERK FAK cancer biology carcinogenesis mouse
Mesh : Animals Proto-Oncogene Proteins B-raf / metabolism genetics Phosphorylation Mice Humans Cecal Neoplasms / metabolism genetics pathology Focal Adhesion Kinase 1 / metabolism genetics Extracellular Signal-Regulated MAP Kinases / metabolism genetics MAP Kinase Signaling System ErbB Receptors / metabolism genetics Carcinogenesis / genetics metabolism Receptors, G-Protein-Coupled / metabolism genetics Male
来 源:
DOI:10.7554/eLife.94605
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