PDF(Pubmed)
Abstract：
BACKGROUND: Schistosome egg deposition in pregnant women may affect the placenta of infected mothers and cause placental schistosomiasis (PS). Histopathological examination of placental tissue is an inadequate detection method due to low sensitivity. So far, there has not been any systematic review on PS.
METHODS: We conducted a systematic literature search on PubMed, EMBASE, and Medline and included all publications that reported microscopically confirmed cases of PS, as well as the relevant secondary literature found in the citations of the primarily included publications.
RESULTS: Out of 113 abstracts screened we found a total of 8 publications describing PS with a total of 92 cases describing egg deposition of dead and/or viable eggs and worms of S. haematobium and S. mansoni in placental tissue. One cross-sectional study investigating the prevalence of PS and its association with adverse birth outcomes, found 22% of placentas to be infested using a maceration technique but only <1% using histologic examination. Additionally, no direct link to deleterious pregnancy outcomes could be shown.
CONCLUSIONS: PS is a highly unattended and underdiagnosed condition in endemic populations, due to a lack of awareness as well as low sensitivity of histopathological examinations. However, PS may play an important role in mediating or reinforcing adverse birth outcomes (ABO) such as fetal growth restriction (FGR) in maternal schistosomiasis, possibly by placental inflammation.
METHODS: We conducted a systematic literature search on PubMed, EMBASE, and Medline and included all publications that reported microscopically confirmed cases of PS, as well as the relevant secondary literature found in the citations of the primarily included publications.
RESULTS: Out of 113 abstracts screened we found a total of 8 publications describing PS with a total of 92 cases describing egg deposition of dead and/or viable eggs and worms of S. haematobium and S. mansoni in placental tissue. One cross-sectional study investigating the prevalence of PS and its association with adverse birth outcomes, found 22% of placentas to be infested using a maceration technique but only <1% using histologic examination. Additionally, no direct link to deleterious pregnancy outcomes could be shown.
CONCLUSIONS: PS is a highly unattended and underdiagnosed condition in endemic populations, due to a lack of awareness as well as low sensitivity of histopathological examinations. However, PS may play an important role in mediating or reinforcing adverse birth outcomes (ABO) such as fetal growth restriction (FGR) in maternal schistosomiasis, possibly by placental inflammation.
摘要：
背景：孕妇血吸虫卵沉积可能会影响感染母亲的胎盘并引起胎盘血吸虫病（PS）。由于灵敏度低,胎盘组织的组织病理学检查是不充分的检测方法。到目前为止,尚未对PS进行任何系统的审查。
方法：我们对PubMed进行了系统的文献检索，EMBASE,和Medline，包括所有报告经显微镜确认的PS病例的出版物，以及主要收录出版物的引文中发现的相关次要文献。
结果：在筛选的113份摘要中，我们发现共有8份出版物描述了PS，共有92例描述了死亡和/或存活的卵和蠕虫的卵沉积。在胎盘组织中。一项横断面研究调查了PS的患病率及其与不良分娩结局的关系，使用浸渍技术发现22％的胎盘被感染，但使用组织学检查仅<1％。此外,没有显示与不良妊娠结局的直接联系.
结论：PS是地方性人群中高度无人看管和未诊断的疾病，由于缺乏意识以及组织病理学检查的敏感性低。然而,PS可能在介导或加强不良出生结局（ABO），如胎儿生长受限（FGR）在母体血吸虫病中起重要作用，可能是胎盘炎症。
方法：我们对PubMed进行了系统的文献检索，EMBASE,和Medline，包括所有报告经显微镜确认的PS病例的出版物，以及主要收录出版物的引文中发现的相关次要文献。
结果：在筛选的113份摘要中，我们发现共有8份出版物描述了PS，共有92例描述了死亡和/或存活的卵和蠕虫的卵沉积。在胎盘组织中。一项横断面研究调查了PS的患病率及其与不良分娩结局的关系，使用浸渍技术发现22％的胎盘被感染，但使用组织学检查仅<1％。此外,没有显示与不良妊娠结局的直接联系.
结论：PS是地方性人群中高度无人看管和未诊断的疾病，由于缺乏意识以及组织病理学检查的敏感性低。然而,PS可能在介导或加强不良出生结局（ABO），如胎儿生长受限（FGR）在母体血吸虫病中起重要作用，可能是胎盘炎症。
