PDF(Pubmed)
Abstract：
African horse sickness is a devastating viral disease of equids. It is transmitted by biting midges of the genus Culicoides with mortalities reaching over 90% in naïve horses. It is endemic to sub-Saharan Africa and is seasonally endemic in many parts of southern Africa. However, outbreaks in Europe and Asia have occurred that caused significant economic issues. There are attenuated vaccines available for control of the virus but concerns regarding the safety and efficacy means that alternatives are sought. One promising alternative is the use of virus-like particles in vaccine preparations, which have the potential to be safer and more efficacious as vaccines against African horse sickness. These particles are best made in a complex, eukaryotic system, but due to technical challenges, this may cause significant economic strain on the developing countries most affected by the disease. Therefore, this review also summarises the success so far, and potential, of recombinant protein expression in plants to reduce the economic strain of production.
摘要：
非洲马病是一种毁灭性的马匹病毒性疾病。它是通过咬Culicoides属的mid传播的，在幼稚的马中死亡率达到90％以上。它是撒哈拉以南非洲的地方病，在南部非洲的许多地方是季节性地方病。然而,欧洲和亚洲的疫情已经发生，造成了重大的经济问题。存在可用于控制病毒的减毒疫苗,但对安全性和功效的担忧意味着寻求替代品。一个有希望的替代方案是在疫苗制剂中使用病毒样颗粒，作为预防非洲马病的疫苗，它们有可能更安全、更有效。这些粒子最好是在复合体中制造的，真核系统，但是由于技术挑战，这可能会对受该疾病影响最大的发展中国家造成巨大的经济压力。因此,这次审查也总结了迄今为止的成功，和潜力，重组蛋白在植物中的表达，以减少经济菌株的生产。
